Subscribe to RSS
A report of the frequency of colorectal carcinoma and involved lymph nodes in South-West IranFinancial support and sponsorship Nil.
Context: The colorectal cancer (CRC) is the most common malignancy between men and women. CRC has considerable morbidity and mortality, with more than 1000,000 new cases and 500,000 annual deaths. Regional lymph nodes are most common sites of metastasis from colon cancer. Lymph node involvement is an essential factor in enabling the accurate evaluation of prognosis in CRC patients. Aims: In this study, we focused on the frequency of CRC and involved lymph nodes and adequacy of lymph node dissection in patients who referred to the Oncology and Radiotherapy Department of Golestan Hospital in Ahvaz City located in South-West Iran. Setting and Design: We conducted a retrospective study among patients receiving surgical treatment for CRC in the Department of Oncology and Radiotherapy of Golestan Hospital in Ahvaz City located in South-West Iran between 2001 and 2010. Methods and Materials: All patients who underwent resection for CRC by open or laparoscopic approaches were included in the study. Data were collected from patients′ medical records. Statistical Analysis Used: Statistical data were analyzed using SPSS 21. Results: A total of 585 cases with CRC aged from16 to 89 years with mean age of 53-year-old were studied. Average number of dissected nodes was 8 lymph nodes, and lymph nodes were not found in pathology specimen of 61 cases (10.4%). In 199 patients (34.01%), number of dissected lymph nodes was 12 or more and in 386 patients (65.98%), number of dissected lymph nodes was <12. Conclusion: This study revealed a large amount of patients that had been under over treatment with radiotherapy and the following inability. Lack of removal of sufficient tissue by the surgeon during surgery or an inadequate sample check by a pathologist might lead to an inability to correct staging of the disease as well as the inability to determine the treatment program of the patients and over treatment with radiotherapy and chemotherapy.
Article published online:
12 July 2021
© 2016. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
- 1 Kumar M, Nagpal R, Verma V, Kumar A, Kaur N, Hemalatha R, et al. Probiotic metabolites as epigenetic targets in the prevention of colon cancer. Nutr Rev 2013;71:23-34.
- 2 Strul H, Arber N. Screening techniques for prevention and early detection of colorectal cancer in the average-risk population. Gastrointest Cancer Res 2007; 1:98-106.
- 3 Todosi AM, Gavrilescu MM, Anitei GM, Filip B, Scripcariu V. Colon cancer at the molecular level - Usefulness of epithelial-mesenchymal transition analysis. Rev Med Chir Soc Med Nat Iasi 2012;116:1106-11.
- 4 Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74-108.
- 5 Gao P, Song YX, Wang ZN, Xu YY, Tong LL, Sun JX, et al. Is the prediction of prognosis not improved by the seventh edition of the TNM classification for colorectal cancer? Analysis of the surveillance, epidemiology, and end results (SEER) database. BMC Cancer 2013;13:123.
- 6 Hanna WC, Ponsky TA, Trachiotis GD, Knoll SM. Colon cancer metastatic to the lung and the thyroid gland. Arch Surg 2006;141:93-6.
- 7 Montemurro S, Maselli E, Ruggieri E, Caliandro C, Rucci A, Zito AF, et al. Isolated splenic metastasis from colon cancer. Report of a case. Tumori 2008;94:422-5.
- 8 Chang GJ, Rodriguez-Bigas MA, Skibber JM, Moyer VA. Lymph node evaluation and survival after curative resection of colon cancer: Systematic review. J Natl Cancer Inst 2007;99:433-41.
- 9 Lacaine F. Lymphadenectomy in the treatment of colon cancer. J Chir (Paris) 2008;145 Spec no 4:12S36-9.
- 10 Labianca R, Milesi L, Mosconi S, Pessi MA, Beretta GD, Quadri A. The role of adjuvant chemotherapy in colon cancer. Surg Oncol 2007;16 Suppl 1:S93-6.
- 11 Wright FC, Law CH, Berry S, Smith AJ. Clinically important aspects of lymph node assessment in colon cancer. J Surg Oncol 2009;99:248-55.
- 12 Vendramini DL, Albuquerque MM, Schmidt EM, Rossi-Junior EE, Gerent Wde A, Cunha VJ. Laparoscopic and open colorectal resections for colorectal cancer. Arq Bras Cir Dig 2012;25:81-7.
- 13 Yacoub M, Swistak S, Chan S, Chichester T, Dawood S, Berri R, et al. Factors that influence lymph node retrieval in the surgical treatment of colorectal cancer: A comparison of the laparoscopic versus open approach. Am J Surg 2013;205:339-42.
- 14 Lombardi L, Gebbia V, Silvestris N, Testa A, Colucci G, Maiello E. Adjuvant therapy in colon cancer. Oncology 2009;77 Suppl 1:50-6.
- 15 Boncheva V, Bonney SA, Brooks SE, Tangney M, O′Sullivan G, Mirnezami A, et al. New targets for the immunotherapy of colon cancer-does reactive disease hold the answer? Cancer Gene Ther 2013;20:157-68.