CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2016; 37(01): 20-24
DOI: 10.4103/0971-5851.177010
ORIGINAL ARTICLE

Bacteriological profile and antibiotic susceptibility patterns of clinical isolates in a tertiary care cancer center

Vivek Bhat
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Sudeep Gupta
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Rohini Kelkar
TMH, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Sanjay Biswas
TMH, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Navin Khattry
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Aliasgar Moiyadi
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Prashant Bhat
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Reshma Ambulkar
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Preeti Chavan
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Shubadha Chiplunkar
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Amol Kotekar
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
,
Tejpal Gupta
ACTREC, Tata Memorial Centre, Kharghar, Mumbai, Maharashtra, India
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Introduction: This increased risk of bacterial infections in the cancer patient is further compounded by the rising trends of antibiotic resistance in commonly implicated organisms. In the Indian setting this is particularly true in case of Gram negative bacilli such as Escherichia coli, Klebsiella pneumoniae and Acinetobacter spp. Increasing resistance among Gram positive organisms is also a matter of concern. The aim of this study was to document the common organisms isolated from bacterial infections in cancer patients and describe their antibiotic susceptibilities. Methods: We conducted a 6 month study of all isolates from blood, urine, skin/soft tissue and respiratory samples of patients received from medical and surgical oncology units in our hospital. All samples were processed as per standard microbiology laboratory operating procedures. Isolates were identified to species level and susceptibility tests were performed as per Clinical Laboratory Standards Institute (CLSI) guidelines -2012. Results: A total of 285 specimens from medical oncology (114) and surgical oncology services (171) were cultured. Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Acinetobacter spp. were most commonly encountered. More than half of the Acinetobacter strains were resistant to carbapenems. Resistance in Klebsiella pneumoniae to cephalosporins, fluoroquinolones and carbapenems was >50%. Of the Staphylococcus aureus isolates 41.67% were methicillin resistant. Conclusion: There is, in general, a high level of antibiotic resistance among gram negative bacilli, particularly E. coli, Klebsiella pneumoniae and Acinetobacter spp. Resistance among Gram positives is not as acute, although the MRSA incidence is increasing.



Publication History

Article published online:
12 July 2021

© 2016. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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