Abstract
Background: Eosinophilic granuloma (EG) of bone refers to a generally benign form of Langerhans
cell histiocytosis localized to the bone. Patients may present with a solitary lesion
(monostotic) or multiple sites of involvement (polyostotic). Materials and Methods: This study was done to evaluate the clinicopathological pattern of 6 cases of EGs
of the skull diagnosed at a tertiary care hospital. All patients of EG were included
with the help of medical records over a 5-year period that is, November 2009 to November
2014. They all had been preoperatively evaluated by skull X-ray and computed tomography.
To rule out a multifocal disease scintigraphy was performed in all cases preoperatively.
Surgical excision was performed, and EG was diagnosed on histopathology and immunohistochemistry.
Results: There was a male predominance. Parietal bone was the most common affected bone. Total
excision of the lesion was performed in all cases. No patient received postoperative
radiotherapy. The follow-up period ranged from 6 months to 3 years. No tumor recurrence
was noted. Conclusion: With an unknown etiology, nonspecific clinical and radiological findings with diagnosis
possible only on histopathological examination, EG needs to be considered in the differential
diagnosis as a skull mass, especially in children.
Keywords
Eosinophilic granuloma - histiocytosis - skull
