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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2015; 36(03): 183-185
DOI: 10.4103/0971-5851.166744
ORIGINAL ARTICLE

Clinicopathological pattern of cranial unifocal Langerhans cell histiocytosis: A study at medical college hospital

Salma Bhat
Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India
,
Parvez Nazir
Department of Radiodiagnosis, Real Scan Imaging and Diagnostic Centre, Srinagar, Jammu and Kashmir, India
,
Humaira Bashir
Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India
,
Ruby Reshi
Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India
,
Sheema Sheikh
Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India
,
Rohi Wani
Department of Pathology, Government Medical College, Srinagar, Jammu and Kashmir, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Background: Eosinophilic granuloma (EG) of bone refers to a generally benign form of Langerhans cell histiocytosis localized to the bone. Patients may present with a solitary lesion (monostotic) or multiple sites of involvement (polyostotic). Materials and Methods: This study was done to evaluate the clinicopathological pattern of 6 cases of EGs of the skull diagnosed at a tertiary care hospital. All patients of EG were included with the help of medical records over a 5-year period that is, November 2009 to November 2014. They all had been preoperatively evaluated by skull X-ray and computed tomography. To rule out a multifocal disease scintigraphy was performed in all cases preoperatively. Surgical excision was performed, and EG was diagnosed on histopathology and immunohistochemistry. Results: There was a male predominance. Parietal bone was the most common affected bone. Total excision of the lesion was performed in all cases. No patient received postoperative radiotherapy. The follow-up period ranged from 6 months to 3 years. No tumor recurrence was noted. Conclusion: With an unknown etiology, nonspecific clinical and radiological findings with diagnosis possible only on histopathological examination, EG needs to be considered in the differential diagnosis as a skull mass, especially in children.

Keywords

Eosinophilic granuloma - histiocytosis - skull


Publication History

Article published online:
12 July 2021

© 2015. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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