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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2015; 36(03): 172-175
DOI: 10.4103/0971-5851.166734
ORIGINAL ARTICLE

Neoadjuvant chemotherapy in technically unresectable carcinoma of external auditory canal

Amit Joshi
Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Nidhi Tandon
Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Vanita Noronha
Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Sachin Dhumal
Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Vijay Patil
Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Supreeta Arya
Department of Radiology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Shashikant Juvekar
Department of Radiology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Jaiprakash Agarwal
Department of Radio-diagnosis, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Anil DCruz
Department of Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Prathmesh Pai
Department of Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
,
Kumar Prabhash
Department of Medical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Background: Carcinoma of external auditory canal (EAC) is a very rare malignancy with surgical resection as the main modality of treatment. The outcomes with nonsurgical modalities are very dismal. We present a retrospective analysis of 4 patients evaluating the role of neoadjuvant chemotherapy in technically unresectable cancers. Materials and Methods: This is a retrospective analysis of 4 patients from our institute from 2010 to 2014 with carcinoma EAC who were deemed unfit for surgery due to extensive disease involving occipital bone with soft tissue infiltration (n = 2), temporal dura (n = 1), left temporal lobe, and extensive soft tissue involvement (n = 1). All these patients received neoadjuvant chemotherapy with docetaxel, cisplatin and 5 fluorouracil (n = 3) and paclitaxel and cisplatin (n = 1). Results: Response evaluation showed a partial response (PR) in 3 and stable disease (SD) in 1 patient by Response Evaluation Criteria in Solid Tumors criteria. All 3 patients who received 3 drug chemotherapy had PR while 1 patient who received 2 drug chemotherapy had SD. Two of these patients underwent surgery, and other 2 underwent definitive chemoradiation. One of 3 patients who achieved PR underwent surgical resection; the other 2 remained unresectable in view of the persistent intradural extension and infratemporal fossa involvement. One patient who had SD could undergo surgery in view of clearance of infraatemporal fossa. Recent follow-up shows that 3 out of these 4 patients are alive. Conclusion: This indicates that there may be a role of induction chemotherapy in converting potentially unresectable tumors to resectable disease that could produce better outcomes in carcinoma EAC.

Keywords

Carcinoma of external auditory canal - neoadjuvant chemotherapy - unresectable


Publication History

Article published online:
12 July 2021

© 2015. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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