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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2014; 35(03): 211-214
DOI: 10.4103/0971-5851.142037
ORIGINAL ARTICLE

Plasma cell leukemia: A case series from South India with emphasis on rarer variants

G Rajeswari
Department of Pathology, Nizam′s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
,
T Roshni Paul
Department of Pathology, Nizam′s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
,
Megha S. Uppin
Department of Pathology, Nizam′s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
,
Shantveer G. Uppin
Department of Pathology, Nizam′s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
,
D Raghunadha Rao
Department of Medical Oncology, Nizam′s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
,
D Sree Bhushan Raju D
Department of Nephrology, Nizam′s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
,
G Sadashindu
Department of Medical Oncology, Nizam′s Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
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Abstract

Plasma cell leukemia (PCL) is a rare and aggressive variant of plasma cell dyscrasia. They occur de novo (primary) or as a late manifestation of multiple myeloma (secondary). Patients present with anemia, thrombocytopenia, renal failure, organomegaly and extramedullary manifestations. We are presenting this series as it is the second largest series from India (16) with 4 young cases (under 40 years of age), more number of female patients and two having ′hairy cell′ morphology. It is recommended that techniques like immunophenotyping and protein electrophoresis be performed, whenever the morphology is not characteristic of plasma cells.

Keywords

Immunophenotyping - primary plasma cell leukemia - secondary plasma cell leukemia


Publication History

Article published online:
19 July 2021

© 2014. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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  • References

  • 1 McKenna RW, Kyle RA, Kuehl WM, Grogan TM, Harris NL, Coupland RW. Plasma cell leukemia. In: Swerdlow SH, Campo E, Harris NL, et al., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4 th ed. Lyon, France: IARC; 2008. p. 203.
  • 2 Fernández de Larrea C, Kyle RA, Durie BG, Ludwig H, Usmani S, Vesole DH, et al. Plasma cell leukemia: Consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia 2013;27:780-91.
  • 3 Majumdar N, Kumar R, Anand M, Kalita D, Ghara N, Chopra A, et al. Plasma cell leukemia - A study of 28 cases from India. Hematology 2009;14:198-203.
  • 4 Tembhare PR, Subramanian PG, Sehgal K, Yajamanam B, Kumar A, Gadge V, et al. Immunophenotypic profile of plasma cell leukemia: A retrospective study in a reference cancer center in India and review of literature. Indian J Pathol Microbiol 2011;54:294-8.
  • 5 Naseem S, Kaur S, Gupta R, Kashyap R, Nityanand S. Plasma cell leukemia: Case series from a tertiary center with review of literature. Indian J Hematol Blood Transfus 2012;28:10-4.
  • 6 Kar R, Priyadarshini SG, Niraimathi M, Basu D, Badhe BA. Clinico-pathological spectrum of primary plasma cell leukemia diagnosed at a tertiary care centre in South India over 5 year period. Indian J Hematol Blood Transfus 2012;28:170-4.
  • 7 Raj RS, Najeeb S, Aruna R, Pavithran K, Thomas M. Primary plasma cell leukemia occuring in the young. Indian J Cancer 2003;40:116-7.
  • 8 Kumar TN, Krishnamani K, Gandhi LV, Sadashivudu G, Rao R. Plasma cell leukemia masquerading as hairy cell leukemia: A case report. Indian J Hematol Blood Transfus 2013.
  • 9 van de Donk NW, Lokhorst HM, Anderson KC, Richardson PG. How I treat plasma cell leukemia. Blood 2012;120:2376-89.