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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2014; 35(01): 86-88
DOI: 10.4103/0971-5851.133729
CASE REPORT

Primary anaplastic astrocytoma of the brain after prophylactic cranial irradiation in a case of acute lymphoblastic leukemia: Case report and review of the literature

Imtiaz Ahmed
Department of Radiotherapy and Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Sapna Krishnamurthy
Department of Radiotherapy and Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Aanchal Kakkar
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
,
Pramod Kumar Julka
Department of Radiotherapy and Oncology, All India Institute of Medical Sciences, New Delhi, India
,
Goura Kishor Rath
Department of Radiotherapy and Oncology, All India Institute of Medical Sciences, New Delhi, India
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Abstract

A 6½-year-old boy had developed acute lymphoblastic leukemia and was treated with systemic chemotherapy, intrathecal triple drug regimen and prophylactic cranial irradiation. After 10 years he developed anaplastic astrocytoma of the postero-superior cerebellum on the left side while leukemia was in remission. He was treated with surgical excision, followed by adjuvant three dimensional conformal radiotherapy and is on salvage chemotherapy with temozolamide. It is possible that the anaplastic astrocytoma may be a radiation induced malignancy.

Keywords

Acute lymphoblastic leukemia - anaplastic astrocytoma - prophylactic cranial irradiation


Publication History

Article published online:
19 July 2021

© 2014. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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