CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2013; 34(04): 320-322
DOI: 10.4103/0971-5851.125257
CASE REPORT

Inflammatory myofibroblastic tumor of kidney with heterotopic bone formation: An unusual case mimicking a renal malignancy

Pooja Navale
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India
,
Santosh Menon
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India
,
Ganesh Bakshi
Department of Urologic Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India
,
Ritesh Pruthy
Department of Urologic Oncology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India
,
Sangeeta Desai
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, Maharashtra, India
› Author Affiliations

Abstract

Inflammatory myofibroblastic tumor (IMFT) or pseudotumor is a rare tumor that can be seen in various organs. It is an enigmatic tumor of unknown etiology and difficult to differentiate from malignancy, clinically as well as radiologically. Histologically, it is composed of variable proportions of proliferating spindle myofibroblasts, fibroblasts, extracellular collagen, lymphocytes and plasma cells. This mainly affects the urinary bladder or prostate. Renal involvement is extremely rare and may pose diagnostic difficulty to the clinician. We describe a renal IMFT, mimicking renal malignancy, having unusual histological features.



Publication History

Article published online:
19 July 2021

© 2013. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
  • References

  • 1 Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 1995;19:859-72.
  • 2 Jones EC, Clement PB, Young RH. Inflammatory pseudotumor of the urinary bladder. A clinicopathological, immunohistochemical, ultrastructural, and flow cytometric study of 13 cases. Am J Surg Pathol 1993;17:264-74.
  • 3 Kapusta LR, Weiss MA, Ramsay J, Lopez-Beltran A, Srigley JR. Inflammatory myofibroblastic tumors of the kidney: A clinicopathologic and immunohistochemical study of 12 cases. Am J Surg Pathol 2003;27:658-66.
  • 4 Khallouk A, Ahallal Y, Tazi MF, Elfatemi H, Tazi E, Elammari J, et al. Inflammatory pseudotumor of the kidney: A case report. J Med Case Rep 2011;5:411.
  • 5 Gleason BC, Hornick JL. Inflammatory myofibroblastic tumours: Where are we now? J Clin Pathol 2008;61:428-37.
  • 6 Weiss SW. Histologic Typing of Soft Tissue Tumours. 2 nd ed. New York: Springer Verlag; 1994. p. 48.
  • 7 Arber DA, Kamel OW, van de Rijn M, Davis RE, Medeiros LJ, Jaffe ES, et al. Frequent presence of the epstein-barr virus in inflammatory pseudotumor. Hum Pathol 1995;26:1093-8.
  • 8 Gómez-Román JJ, Sánchez-Velasco P, Ocejo-Vinyals G, Hernández-Nieto E, Leyva-Cobián F, Val-Bernal JF. Human herpesvirus-8 genes are expressed in pulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). Am J Surg Pathol 2001;25:624-9.
  • 9 Selvan DR, Philip J, Manikandan R, Helliwell TR, Lamb GH, Desmond AD. Inflammatory pseudotumor of the Kidney. World J Surg Oncol 2007;5:106.
  • 10 Ro JY, Ayala AG, Sella A, Samuels ML, Swanson DA. Sarcomatoid renal cell carcinoma: Clinicopathologic. A study of 42 cases. Cancer 1987;59:516-26.
  • 11 Gwynn ES, Clark PE. Inflammatory myofibroblastic tumor associated with renal cell carcinoma. Urology 2005;66:880.