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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2013; 34(04): 309-312
DOI: 10.4103/0971-5851.125252
CASE REPORT

Primary mediastinal seminoma; resistance and relapse: An aggressive entity

Ankita Nachankar
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Rahul Krishnatry
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Amit Joshi
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Vanita Noronha
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Jai Prakash Agarwal
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
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Abstract

Seminoma is one of the most radio and chemo sensitive tumors. Aggressive variant of primary mediastinal seminoma (PMS) are rarely described in the literature. We here discuss an interesting case of young male (22 years) presenting with superior vena cava syndrome due to PMS that showed poor response to conventional platinum based chemotherapy and radiotherapy. Furthermore, with a short disease free interval (one year) relapsed at unusual sites of bone and soft-tissue deposits in check. This emphasizes the importance of identifying methods to pre-screen such aggressive variants for more effective treatment options.

Keywords

Bone metastasis - chemoresistance - extra-gonadal germ cell tumor - mediastinal seminoma - radio-resistance - soft-tissue metastasis


Publication History

Article published online:
19 July 2021

© 2013. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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