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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2013; 34(04): 242-246
DOI: 10.4103/0971-5851.125235
ORIGINAL ARTICLE

Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organization classification

Santosh Kumar Mondal
Department of Pathology, Medical College, Kolkata, West Bengal, India
,
Palash Kumar Mandal
Department of Pathology, Medical College, Kolkata, West Bengal, India
,
Tarun Kumar Samanta
Department of Paediatrics, Medical College, Kolkata, West Bengal, India
,
Subrata Chakaborty
Department of Radiotherapy, Medical College, Kolkata, West Bengal, India
,
Saptarshi Dutta Roy
Department of Pathology, Medical College, Kolkata, West Bengal, India
,
Shravasti Roy
Department of Pathology, Thakurpukur Cancer Hospital, Kolkata, West Bengal, India
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Abstract

Background: Malignant lymphoma (ML) is one of the most common cancers and is most prevalent in developed countries. The distribution of different subtypes of ML varies in the different geographical locations according to World Health Organization (WHO) Classification. Aims and Objectives : The study was aimed to analyze the different patterns of ML in Eastern India and to compare it with other geographical locations. Materials and Methods: Four hundred and fifty five patients of two large hospitals in Eastern India were included over a period of four years and were categorized according to WHO classification, using the morphology and immunohistochemistry. Results: There were 347 (76.3%) non Hodgkin lymphomas (NHL), and 108 (23.7%) Hodgkin lymphomas (HL). Diffuse large B-cell lymphoma was the most common of the NHL type (35.2%) followed by the follicular lymphoma (19.3%). B-cell lymphoblastic lymphoma was the least common type of NHL (1.4%). Mixed cellularity (33.3%) and nodular sclerosis (26.9%) were the two most common type of HL. Childhood lymphoma comprised of 12.5%of all ML. T-cell NHL and HL were the common lymphomas in this age group. Conclusion: Incidence of follicular lymphoma is lower compared to western studies and mixed cellularity is the most common subtype of HL unlike nodular sclerosis subtype in Western world. Burkitt′s type NHL though is the most common subtype of childhood ML in many studies. However, in our study, T-cell NHL is the most common type of childhood ML.

Keywords

Eastern India - immunophenotyping - lymphoma - World Health Organization


Publication History

Article published online:
19 July 2021

© 2013. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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