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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2013; 34(03): 213-220
DOI: 10.4103/0971-5851.123748
ORIGINAL ARTICLE

Imatinib mesylate resistance and mutations: An Indian experience

Shweta Srivastava
Department of Molecular Pathology, OncQuest Laboratories Ltd., New Delhi, India
,
Sarjana Dutt
Department of Molecular Pathology, OncQuest Laboratories Ltd., New Delhi, India
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Abstract

The treatment of chronic myeloid leukemia (CML) has been revolutionized by the small molecule selective kinase inhibitor imatinib mesylate. Imanitib was the first BCR-ABL targeted agent approved for the treatment of CML patients and confers significant response in most patients; however, a substantial number of patients are initially refractory to the drug or may develop resistance during the course of treatment. Point mutations in the kinase domain (KD) of BCR-ABL that impact drug binding have been identified as one of the major mechanisms of resistance. We present here an overview of the current practice in monitoring for such mutations, including the methods used, criteria for investigating and guidelines for reporting the mutations. We further present and discuss the experience of our own laboratory in studying the KD mutations in Indian CML patients on imatinib treatment.

Keywords

Chronic myeloid leukemia - imatinib - kinase domain mutations


Publication History

Article published online:
19 July 2021

© 2013. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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