Subscribe to RSS
DOI: 10.4103/0971-5851.123725
Chronic myeloid leukemia treatment with Imatinib: An experience from a private tertiary care hospital
Abstract
The data presents 75 chronic myeloid leukemia patients diagnosed over a period 6 years i.e. from 2002 to 2008. The most common presentation was splenomegaly and 97% achieved complete hematological response at median duration of 4.3 weeks. The uniqueness of this study is follow-up with molecular response monitoring. Nearly, 30% patients achieved major molecular response (MMoR) by 12 months. 70% of patients achieved MMoR by median time of 60 months. Only 10% of the patient who achieved MMoR by 18 months had lost their responses subsequently.
Publication History
Article published online:
19 July 2021
© 2013. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)
Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India
-
References
- 1 Rajappa S, Varadpande L, Paul T, Jacob R, Digumarti R. Imatinib mesylate in early chronic phase chronic myeloid leukemia: Experience from a developing country. Leuk Lymphoma 2008;49:554-8.
- 2 Devetten MP. First-line treatment of patients with chronic-phase myelogenous leukemia: Progress and remaining questions. Community Oncol 2010;7:160-5.
- 3 Hay J, Bapsy PP, Babu KG, Loknatha. Imatinib mesylate in newly diagnosed patients with chronic myeloid leukaemia. ASCO annual meeting proceedings. J Clin Oncol 2007;25:17251.
- 4 Aziz Z, Iqbal J, Akram M, Saeed S. Treatment of chronic myeloid leukemia in the imatinib era: Perspective from a developing country. Cancer 2007;109:1138-45.
- 5 Arora B, Kumar L, Kumari M, Sharma A, Wadhwa J, Kochupillai V. Therapy with imatinib mesylatefor chronic myeloid leukemia. Indian J Med Paediatr Oncol 2005;26:5-16.
- 6 Deshmukh C, Saikia T, Bakshi A, Amare-Kadam P, Baisane C, Parikh P. Imatinib mesylate in chronic myeloid leukemia: A prospective, single arm, non-randomized study. J Assoc Physicians India 2005;53:291-5.
- 7 Wang L, Pearson K, Pillitteri L, Ferguson JE, Clark RE. Serial monitoring of BCR-ABL by peripheral blood real-time polymerase chain reaction predicts the marrow cytogenetic response to imatinib mesylate in chronic myeloid leukaemia. Br J Haematol 2002;118:771-7.
- 8 Gupta A, Prasad K. Hematological and molecular response evaluation of CML patients on imatinib. J Assoc Physicians India 2007;55:109-13.
- 9 Medhi K, Raina V, Kumar L, Sharma A, Bakhshi S, Gupta R, et al. Response assessment of patients with chronic myeloid leukemia receiving imatinib mesylate (Glivec) therapy: Experience from a single center in a developing country. Leuk Lymphoma 2010;51:1850-4.