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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2013; 34(01): 34-37
DOI: 10.4103/0971-5851.113420
CASE REPORT

Case of childhood laryngeal papillomatosis with metastatic carcinoma esophagus in adulthood

Nishitha Shetty
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Kumar Prabhash
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Amit Joshi
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Suhail I. Sayed
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Shilpi Sharma
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Vanita Noronha
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Anuja Deshmukh
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Devendra Chaukar
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
S Kane
Department of Pathology, Tata Memorial Hospital, Mumbai, Maharashtra, India
,
Gopal,
Anil K. D′cruz
Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
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Abstract

A young male patient was diagnosed to have laryngeal papillomas at the age of 3 years for which he underwent permanent tracheostomy and also multiple surgical and laser excision procedures. Then, later in life, the patient had progressive breathlessness and dysphagia. On examination, he had supraclavicular lymphadenopathy showing squamous carcinoma pathology. Since laryngeal papillomas have a high propensity to transform into laryngeal squamous cell carcinoma, he was first evaluated for laryngeal carcinoma which was negative. Esophagoscopy showed a growth in the esophagus, the biopsy of which was positive for squamous malignant cells. Patient was then started on palliative chemotherapy with combination of paclitaxel and carboplatin, and at progression with weekly nanoxel with stable disease. This is a rare case of childhood laryngeal papillomatosis progressing to metastatic esophageal carcinoma. This case has been presented to highlight the fact that patients with laryngeal papillomas are not only at high risk of progressing to laryngeal carcinoma but can also have other malignancies of the upper aerodigestive tract and lung. Most of them have been correlated to human papilloma virus (HPV), but in our patient HPV DNA was negative.

Keywords

Larynx - papillomatosis - carcinoma esophagus


Publication History

Article published online:
20 July 2021

© 2013. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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