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CC BY-NC-ND 4.0 · Indian J Med Paediatr Oncol 2012; 33(03): 166-169
DOI: 10.4103/0971-5851.103144
ORIGINAL ARTICLE

Rare and recurrent chromosomal abnormalities and their clinical relevance in pediatric acute leukemia of south Indian population

Seyed Hashem Mir Mazloumi
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India
,
Prasanna Kumari
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India
,
D S Madhumathi
Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India
,
L Appaji
Department of Pediatric Oncology, Kidwai Memorial Institute of Oncology, Bangalore, Karnataka, India
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Abstract

Background and Objectives: This cytogenetic study detects a wide variety of common, rare and novel chromosomal abnormalities in patients with hematological disorders, providing valuable diagnostic and prognostic information. Materials and Methods: We addressed the utility of the cytogenetic technique in 50 patients of pediatric acute leukemia prospectively. Results: Successful cultures were found in 44 patients (88%) and abnormal karyotypes in 22 (44%). The common abnormalities like hyperdiploidy, del(6q), t(1;19)(q23;p13), t(4;11)(q22;q23), t(9;22)(q34;q11), rare t(2;7)(q23;p11) and t(4;12)(q21;p13) and a novel translocation t(7;9)(q22;q21) were observed in acute lymphoblastic leukemia. In acute myeloid leukemia, t(8;21)(q22;q22), del(16)(q22), t(15;17)(q22;q21) and t(9;11)(p22;q23) were commonly seen. Conclusion: Chromosomal abnormalities of this small group of patients are compared with the relevant literature with respect to the incidence rate and prognosis.

Keywords

Acute leukemia - cytogenetic - diagnosis - karyotype - pediatric


Publication History

Article published online:
02 August 2021

© 2012. Indian Society of Medical and Paediatric Oncology. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)

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