CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2012; 22(01): 58-62
DOI: 10.4103/0971-3026.95406
Neuroradiology and Head & Neck Radiology

Multifocal intracranial astrocytoma in a pediatric patient with Ollier disease

Girish Bathla
Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore
,
Sarika Gupta
Department of Pathology, National University Hospital, Singapore, Singapore
,
Cheng Ong
Department of Diagnostic Imaging, National University Hospital, Singapore, Singapore
› Author Affiliations

Abstract

Ollier disease (OD) is a subtype of enchondromatosis. Historically, it has been distinguished from Maffucci syndrome (MS) by the presence of vascular malformations and nonskeletal neoplasms (NSN) in the latter. However, there is an increasing number of reports of NSN in OD, and this categorization is now being questioned. We report a case of OD complicated by multifocal astrocytoma in a young patient, once again pointing to a possible association between OD and NSN. We also review the available literature and examine the similarities between the reported cases.



Publication History

Article published online:
30 July 2021

© 2012. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Ranger A, Szymczak A, Hammond RR, Zelcer S. Pediatric thalamic glioblastoma associated with Ollier disease (multiple enchondromatosis): A rare case of concurrence. J Neurosurg Pediatr 2009;4:363-7.
  • 2 Hofman S, Heeg M, Klein JP, Krikke AP. Simultaneous occurrence of a supra- and an infratentorial glioma in a patient with Ollier′s disease: More evidence for non-mesodermal tumor predisposition in multiple enchondromatosis. Skeletal Radiol 1998;27:688-91.
  • 3 Chang S, Prados MD. Identical twins with Ollier′s disease and intracranial gliomas: Case report. Neurosurgery 1994;34:903-6.
  • 4 Ranger A, Szymczak A. The association between intracranial tumours and multiple dyschondroplasia (Ollier′s disease or Maffucci′s syndrome): Do children and adults differ? J Neurooncol 2009;95:165-73.
  • 5 Frappaz D, Ricci AC, Kohler R, Bret P, Mottolese C. Diffuse brain stem tumor in an adolescent with multiple enchondroma-tosis (Ollier′s disease). Childs Nerv Syst 1999;15:222-5.
  • 6 Mellon CD, Carter JE, Owen DB. Ollier′s disease and Maffucci′s syndrome: Distinct entities or a continuum. Case report: Enchondromatosis complicated by an intracranial glioma. J Neurol 1998;235:376-8.
  • 7 Balcer LJ, Galetta SL, Cornblath WT, Liu GT. Neuro-ophthalmologic manifestations of Maffucci′s syndrome and Ollier′s disease. J Neuroophthalmol 1999;19:62-6.
  • 8 Hori K, Matsumine A, Niimi R, Maeda M, Uchida K, Nakamura T, et al. Diffuse gliomas in an adolescent with multiple enchondromatosis (Ollier′s disease). Oncol Lett 2010;1:595-7.
  • 9 Becker W, Thron A. Dyschondroplasie mit gliomatosem hirntumor: Oritter histologisch gesicherter fall. Arch Orthop Trauma Surg 1979;93:141-4.
  • 10 Rawlings CE 3rd, Bullard DE, Burger PC, Friedman AH. A case of Ollier′s disease associated with two intracranial gliomas. Neurosurgery 1987;21:400-3.
  • 11 Schwartz HS, Zimmerman NB, Simon MA, Wroble RR, Millar EA, Bonfiglio M. The malignant potential of enchon-dromatosis. J Bone Joint Surg Am 1987;69:269-74.
  • 12 Patt S, Weigel K, Mayer HM. A case of dyschondroplasia associated with brain stem glioma: Diagnosis by stereotactic biopsy. Neurosurgery 1990;27:487-91.
  • 13 Bendel CJ, Gelmers HJ. Multiple enchondromatosis (Ollier′s disease) complicated by malignant astrocytoma. Eur J Radiol 1991;12:135-7.
  • 14 Simsek S, Seckin H, Belin D. Ollier′s disease with intracranial glioma. Turk Norosirurji Derg 2002;12:66-9.
  • 15 Mahafza WS. Multiple enchondromatosis Ollier′s disease with two primary brain tumors. Saudi Med J 2004;25:1261-3.
  • 16 Koc F, Koc Z. Ollier disease anaplastic mixed oligoastrocytoma: A rare association with brain tumors. Neurosurg Q 2006;4:195-7.
  • 17 Walid MS, Troup EC. Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease. J Neurooncol 2008;89:59-62.
  • 18 Kloosterhof NK, Bralten LB, Dubbink HJ, French PJ, Van den Bent MJ. Isocitrate dehydrogenase-1 mutations: A fundamentally new understanding of diffuse glioma? Lancet Oncol 2011;12:83-91.
  • 19 Amary MF, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol 2011;224:334-43.
  • 20 Pansuriya TC, Kroon HM, Bovee JV. Enchondromatosis: Insights on the different subtypes. Int J Clin Exp Pathol 2010;3:557-69.
  • 21 Evliyaoglu C, Carroll R, Folkerth R, Bello L, Bruns DE, Black PM. Parathyroid hormone-related protein and its receptor in human glial tumors. Acta Neurochir (Wien) 2000;142:871-8.