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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2009; 19(04): 287-290
DOI: 10.4103/0971-3026.57209
Breast Radiology

Role of diffusion MRI in characterizing benign and malignant breast lesions

Lalitha Palle
Department of Radiology, Focus Diagnostics, Hyderabad, Andhra Pradesh, India
,
Balaji Reddy
Department of Radiology, Focus Diagnostics, Hyderabad, Andhra Pradesh, India
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Abstract

Aims: The aim of this study was to evaluate the role of MRI based diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for characterizing breast lesions in Indian patients. Materials and Methods : This prospective analysis was performed between October 2006 and June 2008. It includes 200 patients between the ages of 16 and 80 years with solid breast lesions greater than 1 cm in diameter. Of these 200 patients, 80 underwent breast MRI with contrast and DWI. One hundred and twenty patients had only DWI as they had come only for sonomammography. A total of 280 lesions were detected. ADC values were calculated for all the lesions and the highest and lowest values of ADC for benign and malignant lesions were identified. Finally, we compared our findings with those of previous studies. Results : Two hundred and eight lesions were categorized as benign and 72 lesions were categorized as malignant based on the ADC values. Based on previous data, lesions with ADC values from 1.3 to 1.5 mm 2 /s were considered benign where as lesions with ADC values ranging between 0.85 and1.1 mm 2 /s were considered malignant. Two lesions whose ADC values were in the benign range were proven to be malignant tumors after surgery. This method of using ADC values for the detection of malignant lesions showed a sensitivity of 97.22% and a specificity of 100%. The positive predictive value was 100%. Conclusion : DWI is a useful technique for characterizing breast tumors, especially for lesions that cannot be adequately characterized by ultrasonography and routine magnetic resonance imaging.

Keywords

Apparent diffusion coeffi cient - diffusion - MRI


Publication History

Article published online:
02 August 2021

© 2009. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Guo Y, Cai YQ, Cai ZL, Gao YG, An NY, Ma L, et al. Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging. J Magn Reson Imaging 2002;16:172-8
  • 2 Park MJ, Cha ES, Kang BJ, Ihn YK, Baik JH. The role of diffusion-weighted imaging and the Apparent Diffusion Coefficient (ADC) values for breast tumors. Korean J Radiol 2007;8:390-6.
  • 3 Basser PJ. Diffusion and diffusion tensor imaging In: Atlas SW, editor. Magnetic resonance imaging of brain and spine. 3 rd ed. Philadelphia: Lippincot Williams and Wilkins; 2002. p. 197-212.
  • 4 Schaefer PW, Grant PE, Gonzalez RG. Diffusion weighted MR imaging of brain. Radiology 2000;217:331-45.
  • 5 Odoguardi F, Cilotti A, Marini C, Moretti M, Mazzotta D, Vaccaro A, et al. Role of Diffusion-Weighted Imaging (DWI) in Magnetic Resonance (MR) of the breast. University of PISA, Italy: 2005.
  • 6 Yili Z, Xiaoyan H, Hongwen D, Yun Z, Xin C, Peng W, et al. The value of diffusion-weighted imaging in assessing changes of tissues adjacent to breast carcinoma. BMC Cancer 2009;9:18.
  • 7 Drew PJ, Chatterjee S, Turnbull LW, Read J, Carleton PJ, Fox JN, et al. Dymanic contrast enhanced magnetic resonance imaging of breast is superior to triple assessment for pre-operative detection of multifocal breast cancer. Ann Surg Oncol 1999;6:599-603.
  • 8 Yabuuchi H, Matsuo Y, Okafuji T, Kamitani T, Soeda H, Setoguchi T, et al. Enhanced mass on contrast enhanced breast MR imaging: Lesion characterization using combination of dynamic contrast enhanced and diffusion weighted MR images. J Magn Reson Imaging 2008;28:1157-65.