CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2015; 25(04): 421-438
DOI: 10.4103/0971-3026.169462
Neuroradiology

Magnetic resonance imaging of optic nerve

Foram Gala
Department of Radiology, Lifescan Imaging Centre, Mumbai, Maharashtra, India; Department of Neuroradiology, University Hospital of Zurich/Children's Hospital of Zurich, Switzerland, Switzerland
› Author Affiliations
Financial support and sponsorship Nil.

Abstract

Optic nerves are the second pair of cranial nerves and are unique as they represent an extension of the central nervous system. Apart from clinical and ophthalmoscopic evaluation, imaging, especially magnetic resonance imaging (MRI), plays an important role in the complete evaluation of optic nerve and the entire visual pathway. In this pictorial essay, the authors describe segmental anatomy of the optic nerve and review the imaging findings of various conditions affecting the optic nerves. MRI allows excellent depiction of the intricate anatomy of optic nerves due to its excellent soft tissue contrast without exposure to ionizing radiation, better delineation of the entire visual pathway, and accurate evaluation of associated intracranial pathologies.



Publication History

Article published online:
30 July 2021

© 2015. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

Thieme Medical and Scientific Publishers Private Ltd.
A-12, Second Floor, Sector -2, NOIDA -201301, India

 
  • References

  • 1 Grainger RG, Allison DJ, Dixon AK. Grainger and Allison's Diagnostic Radiology: A Textbook of Medical Imaging:5th ed. Philadelphia: Elsevier Churchill Livingstone; 2001. p. 1395.
  • 2 Montaleone P. The optic nerve: A clinical perspective. Univ West Ont Med J 2010;79:37-9.
  • 3 Campbell WW, DeJong RN, Haerer AF. DeJong's the Neurologic Examination. 6th ed. Philadelphia: Lippincott Williams and Wilkins; 2005. p. 120.
  • 4 Griessenauer CJ, Raborn J, Mortazavi MM, Tubbs RS, Cohen-Gadol AA. Relationship between the pituitary stalk angle in prefixed, normal, and postfixed optic chiasmata: An anatomic study with microsurgical application. Acta Neurochir (Wien) 2014;156:147-51.
  • 5 Razek AA, Elkhamary S. MRI of retinoblastoma. Br J Radiol 2011;84:775-84.
  • 6 Mafee MF, Rapoport M, Karimi A, Ansari SA, Shah J. Orbital and ocular imaging using 3- and 1.5-T MR imaging systems. Neuroimaging Clin N Am 2005;15:1-21.
  • 7 Brodsky MC. Anomalies of the optic disc. In: Miller NR, Newman NJ, editors. Walsh and Hoyt's Clinical Neuro-Ophthalmology. Vol. 1. 5th ed. Baltimore: Williams and Wilkins; 1998. p. 799-800.
  • 8 Brodsky MC. Congenital optic disc anomalies. In: Taylor D, Hoyt G, editors. Pediatric Ophthalmology and Strabismus. 3rd ed. Edinburgh: Elsevier-Saunders; 2005. p. 637-8.
  • 9 Azuma N, Yamaguchi Y, Handa H, Tadokoro K, Asaka A, Kawase E, et al. Mutations of the PAX6 gene detected in patients with a variety of optic-nerve malformations. Am J Hum Genet 2003;72:1565-70.
  • 10 Denis D, Girard N, Levy-Mozziconacci A, Berbis J, Matonti F. Ocular coloboma and results of brain MRI: Preliminary results. J Fr Ophtalmol 2013;36:210-20.
  • 11 Kalra VB, Gilbert JW, Levin F, Malhotra A. Spectrum of MRI findings in morning glory syndrome. Neurographics 2014;4:56-60.
  • 12 Ellika S, Robson CD, Heidary G, Paldino MJ. Morning glory disc anomaly: Characteristic MR imaging findings. AJNR Am J Neuroradiol 2013;34:2010-4.
  • 13 Borchert M, Garcia-Filion P. The syndrome of optic nerve hypoplasia. Curr Neurol Neurosci Rep 2008;8:395-403.
  • 14 Haddad NG, Eugster EA. Hypopituitarism and neurodevelopmental abnormalities in relation to central nervous system structural defects in children with optic nerve hypoplasia. J Pediatr Endocrinol Metab 2005;18:853-8.
  • 15 Kelberman D, Dattani MT. Genetics of septo-optic dysplasia. Pituitary 2007;10:393-407.
  • 16 Webb EA, Dattani MT. Septo-optic dysplasia. Eur J Hum Genet 2010;18:393-7.
  • 17 Al-Senawi R, Al-Jabri B, Al-Zuhaibi S, Al-Azri F, Al-Yarubi S, Harikrishna B, et al. Septo-optic dysplasia complex: Clinical and radiological manifestations in Omani children. Oman J Ophthalmol 2013;6:193-8.
  • 18 Dempsey MA, Torres-Martinez W, Walsh LE. Two cases further delineating the Sakoda complex. Am J Med Genet A 2007;143A: 370-6.
  • 19 Yu-Wai-Man P, Chinnery PF. Leber hereditary optic neuropathy. In: Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, et al., editors. GeneReviews ®. Seattle, WA: University of Washington; 1993-2015. .
  • 20 Viswanathan V, Medempudi S, Kadiri M. Wolfram syndrome. J Assoc Physicians India 2008;56:197-9.
  • 21 Hittmair K, Wimberger D, Wiesbauer P, Zehetmayer M, Budka H. Early infantile form of Krabbe disease with optic hypertrophy: Serial MR examinations and autopsy correlation. AJNR Am J Neuroradiol 1994;15:1454-8.
  • 22 Bernal OG, Lenn N. Multiple cranial nerve enhancement in early infantile Krabbe's disease. Neurology 2000;54:2348-9.
  • 23 Jones BV, Barron TF, Towfighi J. Optic nerve enlargement in Krabbe's disease. AJNR Am J Neuroradiol 1999;20:1228-31.
  • 24 Shetty SB, Mehta C. Langerhans cell histiocytosis of the orbit. Indian J Ophthalmol 2001;49:267-8.
  • 25 Zimmerman LE. Ocular lesions of juvenile xanthogranuloma. Nevoxanthoendothelioma. Am J Ophthalmol 1965;69:1011-35.
  • 26 Miller NR. Primary tumours of the optic nerve and its sheath. Eye (Lond) 2004;18:1026-37.
  • 27 Lin YC, Wang AG, Yen MY, Hsu WM. Leukaemic infiltration of the optic nerve as the initial manifestation of leukaemic relapse. Eye (Lond) 2004;18:546-50.
  • 28 Jacquemin C, Bosley TM, Liu D, Svedberg H, Buhaliqa A. Reassessment of sphenoid dysplasia associated with neurofibromatosis type 1. AJNR Am J Neuroradiol 2002;23:644-8.
  • 29 Jacquemin C, Bosley TM, Svedberg H. Orbit deformities in craniofacial neurofibromatosis type 1. AJNR Am J Neuroradiol 2003;24:1678-82.
  • 30 Osborn A. Diagnostic Neuroradiology. 4th ed. St. Louis, Missouri:Mosby; 1994. p. 72-84.
  • 31 Beck RW, Trobe JD, Moke PS, Gal RL, Bhatti MT, et al. High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: Experience of the optic neuritis treatment trial. Arch Ophthalmol 2003;121:944-9.
  • 32 Beck RW, Smith CH, Gal RL, Xing D, Bhatti MT, Brodsky MC, et al.; Optic Neuritis Study Group. Neurologic impairment 10 years after optic neuritis. Arch Neurol 2004;61:1386-9.
  • 33 Cleary PA, Beck RW, Anderson MM Jr, Kenny DJ, Backlund J, Gilbert PR. Design, methods, and conduct of the Optic Neuritis Treatment Trial. Control Clin Trials 1993;14:123-42.
  • 34 Plant GT, Sibtain NA, Thomas D. Hyperacute corticosteroid treatment of optic neuritis at the onset of pain may prevent visual loss: A case series. Mult Scler Int 2011;2011:815068.
  • 35 Beck RW, Trobe JD. What we have learned from Optic Neuritis Treatment Trial. Ophthalmology 1995;102:1504-8.
  • 36 Cohen JA. Emerging therapies for relapsing multiple sclerosis. Arch Neurol 2009;66:821-8.
  • 37 Osborne BJ, Volpe NJ. Optic neuritis and risk of MS: Differential diagnosis and management. Cleve Clin J Med 2009;76:181-90.
  • 38 Levin LA, Lessell S. Risk of multiple sclerosis after optic neuritis. JAMA 2003;290:403-4.
  • 39 Visual function 5 years after optic neuritis: Experience of the Optic Neuritis Treatment Trial. The Optic Neuritis Study Group. Arch Ophthalmol 1997;115:1545-52.
  • 40 Sapuan S, Basri H. Acute disseminated encephalomyelitis (ADEM) presenting with bilateral optic neuritis. Malays J Med Sci 2007;14:71-4.
  • 41 Gean-Marton AD, Vezina LG, Marton KI, Stimac GK, Peyster RG, Taveras JM, et al. Abnormal corpus callosum: A sensitive and specific indicator of multiple sclerosis. Radiology 1991;180:215-21.
  • 42 Kazi AZ, Joshi PC, Kelkar AB, Mahajan MS, Ghawate AS. MRI evaluation of pathologies affecting the corpus callosum: A pictorial essay. Indian J Radiol Imaging 2013;23:321-32.
  • 43 Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. The Lancet Neurology 2007;6:805-15.
  • 44 Kim W, Kim SH, Huh SY, Kim HJ. Brain abnormalities in neuromyelitis optica spectrum disorder. Mult Scler Int 2012;2012:735486.
  • 45 Purvin V, Kawasaki A, Jacobson DM. Optic perineuritis: Clinical and radiographic features. Arch Ophthalmol 2001;119:1299-306.
  • 46 Raghibi A, Hitam WH, Noor RA, Embong Z. Optic perineuritis secondary to tuberculosis: A rare case presentation. Asian Pac J Trop Biomed 2012;2(Suppl 2):S1206-8.
  • 47 Purvin V, Kawasaki A. Optic perineuritis secondary to Wegener's granulomatosis. C Clin Experiment Ophthalmol 2009;37:712-7.
  • 48 Parker SE, Pula JH. Neurosyphilis presenting as asymptomatic optic perineuritis. Case Rep Ophthalmol Med 2012;2012:621872.
  • 49 Osman SS, Ahem A. Value of MRI in diagnosis of giant cell arteritis. Neurol Asia 2012;17:369-72.
  • 50 Huchzermeyer C, Mardin C, Holbach L, Zwerina J, Schett G, Rech J. Successful remission induction with a combination therapy of rituximab, cyclophosphamide, and steroids in a patient with refractory optic neuritis in Wegener's granulomatosis. Clin Rheumatol 2013;32(Suppl 1):S97-101.
  • 51 Agbogu BN, Stern BJ, Sewell C, Yang G. Therapeutic considerations in patients with refractory neurosarcoidosis. Arch Neurol 1995;52:875-9.
  • 52 Yu-Wai-Man P, Crompton DE, Graham JY, Black FM, Dayan MR. Optic perineuritis as a rare initial presentation of sarcoidosis. Clin Experiment Ophthalmol 2007;35:682-4.
  • 53 Palejwala H, Walia H, Yeh S. Ocular manifestations of systemic lupus erythematosus: A review of the literature. Autoimmune Dis 2012;2012:290898.
  • 54 Lin YC, Wang AG, Yen MY. Systemic lupus erythematosus-associated optic neuritis: Clinical experience and literature review. Acta Ophthalmol 2009;87:204-10.
  • 55 Chaudhry IA, Shamsi FA, Arat YO, Riley FC. Orbital pseudotumor: Distinct diagnostic features and management. Middle East Afr J Ophthalmol 2008;15:17-27.
  • 56 Shah R, Roberson GH, Curé JK. Correlation of MR imaging findings and clinical manifestations in neurosarcoidosis. AJNR Am J Neuroradiol 2009;30:953-61.
  • 57 Smith JK, Matheus MG, Castillo M. Imaging manifestations of neurosarcoidosis. AJR Am J Roentgenol 2004;182:289-95.
  • 58 Kornreich L, Blaser S, Schwarz M, Shuper A, Vishne TH, Cohen IJ, et al. Optic pathway glioma: Correlation of imaging findings with the presence of neurofibromatosis. AJNR Am J Neuroradiol 2001;22:1963-9.
  • 59 Turbin RE, Pokorny K. Diagnosis and treatment of orbital optic nerve sheath meningioma. Cancer Control 2004;11:334-41.
  • 60 Kanamalla US. The optic nerve tram-track sign. Radiology 2003;27:718-9.
  • 61 Johnson MD, Aulino JP, Jagasia M, Mawn LA. Erdheim-chester disease mimicking multiple meningiomas syndrome. AJNR Am J Neuroradiol 2004;25:134-7.
  • 62 Fox B, Pacheco P, DeMonte F. Carcinoma of the breast metastatic to the optic nerve mimicking an optic nerve sheath meningioma: Case report and review of the literature. Skull Base 2005;15:281-9.
  • 63 Rauschecker AM, Patel CV, Yeom KW, Eisenhut CA, Gawande RS, O'Brien JM, et al. High-resolution MR imaging of the orbit in patients with retinoblastoma. Radiographics 2012;32:1307-26.
  • 64 Hayreh SS. Orbital vascular anatomy. Eye (Lond) 2006;20:1130-44.
  • 65 Miller NR, Newman NJ, Biousse V, Kerrison JB. Walsh and Hoyt's Clinical Neuro-Ophthalmology. 6th ed. Philadelphia: Lippincott Williams and Wilkins; 2005. p. 30-32.
  • 66 Al-Shafai LS, Mikulis DJ. Diffusion MR imaging in a case of acute ischemic optic neuropathy. AJNR Am J Neuroradiol 2006;27:255-7.
  • 67 Srinivasan S, Moorthy S, Sreekumar K, Kulkarni C. Diffusion-weighted MRI in acute posterior ischemic optic neuropathy. Indian J Radiol Imaging 2012;22:106-7.
  • 68 Degnan AJ, Levy LM. Pseudotumor cerebri: Brief review of clinical syndrome and imaging findings. AJNR Am J Neuroradiol 2011;32:1986-93.
  • 69 Naheedy MH, Haag JR, Azar-Kia B, Mafee MF, Elias DA. MRI and CT of sellar and paresellar disorders. Radio Clin Norrh Am 1987;25:819-47.
  • 70 Gulsen S, Dinc AH, Unal M, Cantürk N, Altinors N. Characterization of the anatomic location of the pituitary stalk and its relationship to the dorsum sellae, tuberculum sellae and chiasmatic cistern. J Korean Neurosurg Soc 2010;47:169-73.
  • 71 Gonçalves AC, Gebrim EM, Monteiro ML. Imaging studies for diagnosing Graves' orbitopathy and dysthyroid optic neuropathy. Clinics (Sao Paulo) 2012;67:1327-34.
  • 72 Purvin V, Kawasaki A, Zeldes S. Dolichoectatic arterial compression of the anterior visual pathways: Neuro-ophthalmic features and clinical course. J Neurol Neurosurg Psychiatry 2004;75:27-32.
  • 73 Piché SL, Haw CS, Redekop GJ, Heran MK. Rare intracanalicular ophthalmic aneurysm: Endovascular treatment and review of the literature. AJNR Am J Neuroradiol 2005;26:1929-31.
  • 74 Day AL. Aneurysms of the ophthalmic segment. A clinical and anatomical analysis. J Neurosurg 1990;72:677-91.
  • 75 Zoumalan CI, Kim JW, Gigantelli JW, Ramadan HH, Talavera F, Batuello SG, et al. Traumatic Optic Neuropathy Treatment and Management. Available from: http://www.emedicine.medscape.com/article/868129. [Last accessed on 10th Oct 2014].
  • 76 Behbehani R. Clinical approach to optic neuropathies. Clin Ophthalmol 2007;1:233-46.