CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2015; 25(02): 184-192
DOI: 10.4103/0971-3026.155871
Abdominal Radiology

Hilar cholangiocarcinoma: Cross sectional evaluation of disease spectrum

Mangal S Mahajan
Department of Radiology, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala, India
,
Srikanth Moorthy
Department of Radiology, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala, India
,
Sreekumar P Karumathil
Department of Radiology, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala, India
,
R Rajeshkannan
Department of Radiology, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala, India
,
Ramchandran Pothera
Department of Radiology, Amrita Institute of Medical Sciences and Research Center, Cochin, Kerala, India
› Author Affiliations

Abstract

Although hilar cholangiocarcinoma is relatively rare, it can be diagnosed on imaging by identifying its typical pattern. In most cases, the tumor appears to be centered on the right or left hepatic duct with involvement of the ipsilateral portal vein, atrophy of hepatic lobe on that side, and invasion of adjacent liver parenchyma. Multi-detector computed tomography (MDCT) and magnetic resonance cholangiopancreatography (MRCP) are commonly used imaging modalities to assess the longitudinal and horizontal spread of tumor.



Publication History

Publication Date:
30 July 2021 (online)

© 2015. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Lazaridis KN, Gores GJ. Cholangiocarcinoma. Gastroenterology 2005;128:1655-67.
  • 2 Slattery JM, Sahani DV. What is the current state-of-the-art imaging for detection and staging of cholangiocarcinomaOncologist 2006;11:913-22.
  • 3 Chung YE, Kim MJ, Park YN, Choi JY, Pyo JY, Kim YC, et al. Varying appearances of cholangiocarcinoma: Radiologic-pathologic correlation. Radiographics 2009;29:683-700.
  • 4 Vanderveen KA, Hussain HK. Magnetic resonance imaging of cholangiocarcinoma. Cancer Imaging 2004;4:104-15.
  • 5 Han JK, Choi BI, Kim AY, An SK, Lee JW, Kim TK, et al. Cholangiocarcinoma: Pictorial essay of CT and cholangiographic findings. Radiographics 2002;22:173-87.
  • 6 Valero V 3 rd , Cosgrove D, Herman JM, Pawlik TM. Management of perihilar cholangiocarcinoma in the era of multimodal therapy. Expert Rev Gastroenterol Hepatol 2012;6:481-95.
  • 7 Suarez-Munoz MA, Fernandez-Aguilar JL, Sanchez-Perez B, Perez-Daga JA, Garcia-Albiach B, Pulido-Roa Y, et al. Risk factors and classifications of hilar cholangiocarcinoma. World J Gastrointest Oncol 2013;5:132-8.
  • 8 Ashkar L, Maheshwari S, Pressacco J, Nakai A, Edelman RR, Reinhold C, el al. MR Cholangiopancreatography. In: Edelman RR, Hesselink J, Zlatkin M, editors. Clinical Magnetic Resonance Imaging. 3 rd ed. Philadelphia: Saunders; 2005. p. 4695-4711.
  • 9 Lim JH. Cholangiocarcinoma: Morphologic classification according to growth pattern and imaging findings. AJRAm J Roentgenol2003;181:819-27.
  • 10 Klatskin G. Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. An unusual tumor with distinctive clinical and pathological features. Am J Med 1965;38:241-56.
  • 11 Papoulas M, Lubezky N, Goykhman Y, Kori I, Santo E, Nakache R, et al. Contemporary surgical approach to hilar cholangiocarcinoma. Isr Med Assoc J 2011;13:99-103.
  • 12 Bismuth H, Corlette MB. Intrahepatic cholangioenteric anastomosis in carcinoma of the hilus of the liver. Surg Gynecol Obstet 1975;140:170-8.
  • 13 Bismuth H, Nakache R, Diamond T. Management strategies in resection for hilar cholangiocarcinoma. Ann Surg 1992;215:31-8.
  • 14 Mansfield SD, Barakat O, Charnley RM, Jaques BC, O′"Suilleabhain CB, Atherton PJ, et al. Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment and outcome. World J Gastroenterol 2005;11:7625-30.
  • 15 Chung YE, Kim MJ, Park YN, Lee YH, Choi JY. Staging of extrahepatic cholangiocarcinoma. Eur Radiol 2008;18:2182-95.
  • 16 House MG, Angelica MD, Jarnagin WR, Jarnagin WR, Blumgart LH. Cancer of the bile ducts: Extrahepatic biliary tumors. In: Jarnagin WR, editor. Blumgart: Surgery of the Liver, Biliary Tract and Pancreas. 5 th ed. Philadelphia: Saunders; 2012. p. 771-88.
  • 17 Liver Cancer Study Group of Japan. The General Rules for the Clinical and Pathological Study of Primary Liver Cancer. 4 th ed. Tokyo, Japan: Kanehara and Co. Ltd; 2000.  
  • 18 Figueras J, Llado L, Valls C, Serrano T, Ramos E, Fabregat J, et al. Changing strategies in diagnosis and management of hilar cholangiocarcinoma. Liver Transpl 2000;6:786-94.
  • 19 Akamatsu N, Sugawara Y, Osada H, Okada T, Itoyama S, Komagome M, et al. Diagnostic accuracy of multidetector-row computed tomography for hilar cholangiocarcinoma. J Gastroenterol Hepatol 2010;25:731-7.
  • 20 Choi JY, Kim MJ, Lee JM, Kim KW, Lee JY, Han JK, et al. Hilar cholangiocarcinoma: Role of preoperative imaging with sonography, MDCT, MRI, and direct cholangiography. AJR Am J Roentgenol 2008;191:1448-57.
  • 21 Feydy A, Vilgrain V, Denys A, Sibert A, Belghiti J, Vullierme MP, et al. Helical CT assessment in hilar cholangiocarcinoma: Correlation with surgical and pathological findings. AJR Am J Roentgenol 1999;172:73-7.
  • 22 Manfredi R, Masselli G, Maresca G, Brizi MG, Marona P. MR imaging and MRCP of hilar cholangiocarcinoma. Abdom Imaging 2003;28:319-25.
  • 23 Valls C, Ruiz S, Martinez L, Leiva D. Radiological diagnosis and staging of hilar cholangiocarcinoma. World J Gastrointest Oncol 2013;5:115-26.
  • 24 Lee HY, Kim SH, Lee JM, Kim SW, Jang JY, Han JK, et al. Preoperative assessment of resectibility of hepatic hilar cholangiocarcinoma: Combined CT and cholangiography with revised criteria. Radiology 2006;239:113-21.
  • 25 Bold RJ, Goodnight JE Jr. Hilar cholangiocarcinoma: Surgical and endoscopic approaches. Surg Clin North Am 2004;84:525-42.
  • 26 Burke EC, Jarnagin WR, Hochwald SN, Pisters PW, Fong Y, Blumgart LH. Hilar Cholangiocarcinoma: Patterns of spread, the importance of hepatic resection for curative operation, and a presurgical clinical staging system. Ann Surg 1998;228:385-94.
  • 27 Yang WL, Zhang XC, Zhang DW, Tong BF. Diagnosis and surgical treatment of hepatic hilar cholangiocarcinoma. Hepatobiliary Pancreat Dis Int 2007;6:631-5.
  • 28 Anaya DA, Blazer DG, Abdalla EK. Strategies for resection using portal vein embolization: Hepatocellular carcinoma and hilar cholangiocarcinoma. Semin Intervent Radiol 2008;25:110-22.
  • 29 Lee TY, Cheon YK, Chim CS. Current status of photodynamic therapy for bile duct cancer. Clin Endosc 2013;46:38-44.
  • 30 Rosen CB, Heimbach JK, Gores GJ. Liver transplantation for cholangiocarcinoma. Transpl Int2010;23:692-7.
  • 31 Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN, Mimics of cholangiocarcinoma: Spectrum of disease. Radiographics 2008;28:1115-29.