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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2015; 25(01): 56-59
DOI: 10.4103/0971-3026.150149
Neuroradiology

Clinical, imaging and histopathological features of isolated CNS lymphomatoid granulomatosis

Anil Kumar Patil
Department of Neurological Sciences, Section of Neurology, Christian Medical College, Vellore, Tamil Nadu, India
,
Mathew Alexander
Department of Neurological Sciences, Section of Neurology, Christian Medical College, Vellore, Tamil Nadu, India
,
Bijesh Nair
Department of Neurological Sciences, Section of Neurosurgery, Christian Medical College, Vellore, Tamil Nadu, India
,
Geeta Chacko
Department of Neurological Sciences, Section of Neuropathology, Christian Medical College, Vellore, Tamil Nadu, India
,
Sunithi Mani
Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
,
Sniya Sudhakar
Department of Radiology, Christian Medical College, Vellore, Tamil Nadu, India
› Author Affiliations Financial support and sponsorship Nil.
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Abstract

Lymphomatoid granulomatosis is a rare systemic angiocentric/angiodestructive, B cell lymphoproliferative disorder. Central nervous system involvement occurs as part of systemic disease. Isolated central nervous system disease is rare with only few case reports. A 53-year-old male presented with progressive cognitive decline, extrapyramidal features, and altered sensorium with seizures over the last 4 years. His magnetic resonance imaging (MRI) of brain showed multiple small enhancing nodules in subependymal/ependymal regions and along the vessels. Brain biopsy showed atypical lymphohistiocytic infiltrate suggestive of lymphomatoid granulomatosis. There was no evidence of systemic disease; thus, isolated central nervous system lymphomatoid granulomatosis was diagnosed.

Keywords

Lymphomatoid granulomatosis - lympho proliferative disorder - nodular enhancing lesions


Publication History

Article published online:
30 July 2021

© 2015. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Lucantoni C, De Bonis P, Doglietto F, Esposito G, Larocca LM, Mangiola A, et al. Primary cerebral lymphomatoid granulomatosis: Report of four cases and literature review. J Neurooncol 2009;94:235-42.
  • 2 Hu YH, Shao ED, Wu JL, Meng XB. Isolated neurological involvement of lymphomatoid granulomatosis. Chin Med J (Engl) 2010;123:3163-6.
  • 3 Liebow AA, Carrington CR, Friedman PJ. Lymphomatoid granulomatosis. Hum Pathol 1972;3:457-558.
  • 4 Rao R, Vugman G, Leslie WT, Loew J, Venugopal P. Lymphomatoid granulomatosis treated with rituximab and chemotherapy. Clin Adv Hematol Oncol 2003;1:658-60.
  • 5 Tateishi U, Terae S, Ogata A, Sawamura Y, Suzuki Y, Abe S, et al. MR imaging of the brain in lymphomatoid granulomatosis. AJNR Am J Neuroradiol 2001;22:1283-90.
  • 6 Patsalides AD, Atac G, Hedge U, Janik J, Grant N, Jaffe ES, et al. Lymphomatoid granulomatosis: Abnormalities of the brain at MR imaging. Radiology 2005;237:265-73.
  • 7 Tagliavini E, Rossi G, Valli R, Zanelli M, Cadioli A, Mengoli MC, et al. Lymphomatoid granulomatosis: A practical review for pathologists dealing with this rare pulmonary lymphoproliferative process. Pathologica 2013;105:111-6.
  • 8 Nishihara H, Nakasato M, Sawa H, Murakami H, Yamamoto D, Moriyama K, et al. A case of central nervous system lymphomatoid granulomatosis; characteristics of PET imaging and pathological findings. J Neurooncol 2009;93:275-8.
  • 9 Kawai N, Miyake K, Nishiyama Y, Yamamoto Y, Sasakawa Y, Haba R, et al. FDG-PET findings of the brain in lymphomatoid granulomatosis. Ann Nucl Med 2006;20:683-7.