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CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2014; 24(01): 22-36
DOI: 10.4103/0971-3026.130688
fMRI-MINI SYMPOSIA

Clinical utility of BOLD fMRI in preoperative work-up of epilepsy

Karthik Ganesan
Department of 3T fMRI, SRL Diagnostics and Jankharia Imaging, Mumbai, Maharashtra, India
,
Meher Ursekar
Department of 3T fMRI, SRL Diagnostics and Jankharia Imaging, Mumbai, Maharashtra, India
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Abstract

Surgical techniques have emerged as a viable therapeutic option in patients with drug refractory epilepsy. Pre-surgical evaluation of epilepsy requires a comprehensive, multiparametric, and multimodal approach for precise localization of the epileptogenic focus. Various non-invasive techniques are available at the disposal of the treating physician to detect the epileptogenic focus, which include electroencephalography (EEG), video-EEG, magnetic resonance imaging (MRI), functional MRI including blood oxygen level dependent (BOLD) techniques, single photon emission tomography (SPECT), and 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET). Currently, non-invasive high-resolution MR imaging techniques play pivotal roles in the preoperative detection of the seizure focus, and represent the foundation for successful epilepsy surgery. BOLD functional magnetic resonance imaging (fMRI) maps allow for precise localization of the eloquent cortex in relation to the seizure focus. This review article focuses on the clinical utility of BOLD (fMRI) in the pre-surgical work-up of epilepsy patients.

Keywords

Blood oxygen dependent level - epilepsy - functional magnetic resonance imaging


Publikationsverlauf

Artikel online veröffentlicht:
02. August 2021

© 2014. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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