CC BY-NC-ND 4.0 · Indian J Radiol Imaging 2013; 23(01): 64-77
DOI: 10.4103/0971-3026.113617
ORIGINAL ARTICLE

Tuberculosis of the genitourinary system-Urinary tract tuberculosis: Renal tuberculosis-Part II

Suleman Merchant
Department of Radiology, LTM Medical College and LTM General Hospital, Mumbai
,
Alpa Bharati
Department of Radiology, LTM Medical College and LTM General Hospital, Mumbai
,
Neesha Merchant
Department of Radiology, University Health Network, University of Toronto, Toronto
› Author Affiliations
Source of Support: Nill.

Abstract

This article reviews the computed tomography and magnetic resonance imaging (MRI) features of renal tuberculosis (TB), including TB in transplant recipients and immunocompromised patients. Multi detector computed tomography (MDCT) forms the mainstay of cross-sectional imaging in renal TB. It can easily identify calcification, renal scars, mass lesions, and urothelial thickening. The combination of uneven caliectasis, with urothelial thickening and lack of pelvic dilatation, can also be demonstrated on MDCT. MRI is a sensitive modality for demonstration of features of renal TB, including tissue edema, asymmetric perinephric fat stranding, and thickening of Gerota′s fascia, all of which may be clues to focal pyelonephritis of tuberculous origin. Diffusion-weighted MR imaging with apparent diffusion coefficient (ADC) values may help in differentiating hydronephrosis from pyonephrosis. ADC values also have the potential to serve as a sensitive non-invasive biomarker of renal fibrosis. Immunocompromised patients are at increased risk of renal TB. In transplant patients, renal TB, including tuberculous interstitial nephritis, is an important cause of graft dysfunction. Renal TB in patients with HIV more often shows greater parenchymal affection, with poorly formed granulomas and relatively less frequent findings of caseation and stenosis. Atypical mycobacterial infections are also more common in immunocompromised patients.



Publication History

Article published online:
04 October 2021

© 2013. Indian Radiological Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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  • References

  • 1 Lu P, Li C, Zhou X. Significance of the CT scan in renal tuberculosis. Zhonghua Jie He He Hu Xi Za Zhi 2001;24:407-9.
  • 2 McCarthy CL, Cowan NC. Multidetector CT urography (MD-CTU) for urothelial imaging (abstr). Radiology 2002;225(P):137.
  • 3 Freiherr G. Will energy replace slices as CT battleground, 2010. Available from: http://www.diagnosticimaging.com/conference-reports/isct2010/content/article/113619/1574376.
  • 4 Zissin R, Gayer G, Chowers M, Shapiro-Feinberg M, Kots E, Hertz M. Computerized tomography findings of abdominal tuberculosis: Report of 19 cases. Isr Med Assoc J 2001;3:414-8.
  • 5 Elkin M. Urogenital tuberculosis. In: Pollack HM, editor. Clinical Urography. Philadelphia: WB Saunders; 1990. p. 1020-52.
  • 6 Leder RA, Low VH. Tuberculosis of the abdomen. Radiol Clin North Am 1995;33:691-705.
  • 7 Premkumar A, Lattimer J, Newhouse JH. CT and sonography of advanced urinary tract tuberculosis. AJR Am J Roentgenol 1987;148:65-9.
  • 8 Browne RF, Zwirewich C, Torreggiani WC. Imaging of urinary tract infection in the adult. Eur Radiol 2004;14:E168-83.
  • 9 Kenney PJ. Imaging of chronic renal infections. AJR Am J Roentgenol 1990;155:485-94.
  • 10 Hartman DS, Stagg PL. Diagnosis please. Case 3: Renal tuberculosis. Radiology 1998;209:69-72.
  • 11 Wang LJ, Wong YC, Chen CJ, Lim KE. CT features of genitourinary tuberculosis. J Comput Assist Tomogr 1997;21:254-8.
  • 12 Pasternak MS, Rubin RH. Urinary tract tuberculosis. In: Schrier RW, editor. Diseases of the Kidney and Urinary Tract. 7th ed. Philadelphia, Pa: Lipincott Williams and Wilkins; 2001. p. 1017-37.
  • 13 Goldman SM, Fishman EK, Hartman DS, Kim YC, Siegelman SS. Computed tomography of renal tuberculosis and its pathological correlates. J Comput Assist Tomogr 1985;9:771-6.
  • 14 Jung YY, Kim JK, Cho KS. Genitourinary tuberculosis: Comprehensive cross-sectional imaging. AJR Am J Roentgenol 2005;184:143-50.
  • 15 Israel GM, Bosniak MA. Pitfalls in renal mass evaluation and how to avoid them. Radiographics 2008;28:1325-38.
  • 16 Kim SH. Urogenital tuberculosis. In: Pollack HM, McClennan BL, editors. Clinical Urography. 2nd ed. Philadelphia, PA: WB Saunders Co; 2000. p. 1193-1228
  • 17 Li Y, Yang ZG, Guo YK, Min PQ, Yu JQ, Ma ES, et al. Distribution and characteristics of hematogenous disseminated tuberculosis within the abdomen on contrast-enhanced CT. Abdom Imaging 2007;32:484-8.
  • 18 Wang LJ, Wu CF, Wong YC, Chuang CK, Chu SH, Chen CJ. Imaging findings of urinary tuberculosis on excretory urography and computerized tomography. J Urol 2003;169:524-8.
  • 19 Goldman SM, Fishman EK. Upper urinary tract infection: The current role of CT, ultrasound, and MRI. Semin Ultrasound CT MR 1991;12:335-60.
  • 20 Gupta H, Kone K, Pandey S, Dorairajan LN, Kumar S. Tubercular mass mimicking a tumour in a horseshoe kidney: A unique presentation. Int Urol Nephrol 2004;36:323-4.
  • 21 Gurski J, Baker KC. An unusual presentation: Renal tuberculosis. ScientificWorldJournal 2008;8:1254-5.
  • 22 Gibson MS, Puckett ML, Shelly ME. Renal tuberculosis. Radiographics 2004;24:251-6.
  • 23 Engin G, Acunaº B, Acunaº G, Tunaci M. Imaging of extrapulmonary tuberculosis. Radiographics 2000;20:471-88.
  • 24 Das KM, Indudhara R, Vaidyanathan S. Sonographic features of genitourinary tuberculosis. AJR Am J Roentgenol 1992;158:327-9.
  • 25 Harisinghani MG, McLoud TC, Shepard JA, Ko JP, Shroff MM, Mueller PR. Tuberculosis from head to toe. Radiographics 2000;20:449-70.
  • 26 Buxi TB, Sud S, Vohra R. CT and MRI in the diagnosis of tuberculosis. Indian J Pediatr 2002;69:965-72.
  • 27 Kawashima A, Sandler CM, Ernst RD, Goldman SM, Raval B, Fishman EK. Renal inflammatory disease: The current role of CT. Crit Rev Diagn Imaging 1997;38:369-415.
  • 28 Muttarak M, ChiangMai WN, Lojanapiwat B. Tuberculosis of the genitourinary tract: Imaging features with pathological correlation. Singapore Med J 2005;46:568-74.
  • 29 Craig WD, Wagner BJ, Travis MD. Pyelonephritis: Radiologic-pathologic review. Radiographics 2008;28:255-77.
  • 30 Miller FH, Parikh S, Gore RM, Nemcek AA Jr, Fitzgerald SW, Vogelzang RL. Renal manifestations of AIDS. Radiographics 1993;13:587-96.
  • 31 Lang EK, Macchia RJ, Thomas R, Watson RA, Marberger M, Lechner G, et al. Improved detection of renal pathologic features on multiphasic helical CT compared with IVU in patients presenting with microscopic hematuria. Urology 2003;61:528-32.
  • 32 Cheng VC, Yew WW, Yuen KY. Molecular diagnostics in tuberculosis. Eur J Clin Microbiol Infect Dis 2005;24:711-20.
  • 33 Okazawa N, Sekiya T, Tada S. Computed tomographic features of renal tuberculosis. Radiat Med 1985;3:209-13.
  • 34 Becker JA. Renal Tuberculosis. Urol Radiol 1988;10:25-30.
  • 35 Merchant SA. Tuberculosis of the Genitourinary System. Indian J Radiol Imaging 1993;3:253-74.
  • 36 Baumgarten DA, Baumgartner BR. Imaging and radiologic management of upper urinary tract infections. Urol Clin North Am 1997;24:545-69.
  • 37 Rabushka LS, Fishman EK, Goldman SM. Pictorial review: Computed tomography of renal inflammatory disease. Urology 1994;44:473-80.
  • 38 Zissin R, Gayer G, Kots E, Werner M, Shapiro-Feinberg M, Hertz M. Iliopsoas abscess: A report of 24 patients diagnosed by CT. Abdom Imaging 2001;26:533-9.
  • 39 Benchekroun A, Lachkar A, Soumana A, Farih MH, Belahnech Z, Marzouk M, et al. Urogenital tuberculosis. 80 cases. Ann Urol (Paris) 1998;32:89-94.
  • 40 Jafri SZ, Roberts JL, Berger BD. Fistulas of the genitourinary tract. In: Pollack HM, editor. Clinical Urography. 2nd ed. Philadelphia: Saunders; 2000. p. 2992-3011.
  • 41 Yu NC, Raman SS, Patel M, Barbaric Z. Fistulas of the genitourinary tract: A radiologic review. Radiographics 2004;24:1331-52.
  • 42 Cooper SG, Richman AH, Tager MG. Nephrocutaneous fistula diagnosed by computed tomography. Urol Radiol 1989;11:33-6.
  • 43 Chen KC. Lymphatic abnormalities in patients with chyluria. J Urol 1971;106:111-4.
  • 44 Haynes JW, Miller PR, Zingas AP. Computed tomography and lymphangiography in chyluria. J Comput Assist Tomogr 1984;8:341-2.
  • 45 Shah HN, Jain P, Chibber PJ. Renal tuberculosis simulating xanthogranulomatous pyelonephritis with contagious hepatic involvement. Int J Urol 2006;13:67-8.
  • 46 Sawczuk IS, Reitelman C, Libby C, Grant D, Vita J, White RD. CT findings in Addison′s disease caused by tuberculosis. Urol Radiol 1986;8:44-5.
  • 47 Anbarasu A, Upadhyay A, Merchant SA, Amonkar P, Devarbhavi H, Bhatnagar M. Tuberculous chylous ascites: Pathognomonic CT findings. Abdom Imaging 1997;22:50-1.
  • 48 Khanna PC, Merchant SA, Joshi AR. Omental cake from tuberculosis. Appl Radiol Imaging 2007;36;5.
  • 49 Georgiades CS, Neyman EG, Barish MA, Fishman EK. Amyloidosis: Review and CT manifestations. Radiographics 2004;24:405-16.
  • 50 Kapoor R, Ansari MS, Mandhani A, Gulia A. Clinical presentation and diagnostic approach in cases of genitourinary tuberculosis. Indian J Urol 2008;24:401-5.
  • 51 Pedrosa I, Sun MR, Spencer M, Genega EM, Olumi AF, Dewolf WC, et al. MR imaging of renal masses: Correlation with findings at surgery and pathologic analysis. Radiographics 2008;28:985-1003.
  • 52 Verswijvel G, Oyen R. Magnetic resonance imaging in the detection and characterization of renal diseases. Saudi J Kidney Dis Transpl 2004;15:283-99.
  • 53 Leyendecker JR, Barnes CE, Zagoria RJ. MR urography: Techniques and clinical applications. Radiographics 2008;28:23-46.
  • 54 Khanna PC, Karnik ND, Jankharia BG, Merchant SA, Joshi AR, Kukreja KU. Magnetic resonance urography (MRU) versus intravenous urography (IVU) in obstructive uropathy: A prospective study of 30 cases. J Assoc Physicians India 2005;53:527-34.
  • 55 Buckley O, Colville J, Torreggiani WC, Leyendecker JR. Re: MR urographic techniques. Radiographics 2008;28:907; author reply 907-8.
  • 56 Kim S, Jacob JS, Kim DC, Rivera R, Lim RP, Lee VS. Time-resolved dynamic contrast-enhanced MR urography for the evaluation of ureteral peristalsis: Initial experience. J Magn Reson Imaging 2008;28:1293-8.
  • 57 Sadowski EA, Bennett LK, Chan MR, Wentland AL, Garrett AL, Garrett RW, et al. Nephrogenic systemic fibrosis: Risk factors and incidence estimation. Radiology 2007;243:148-57.
  • 58 Matsui N, Morita T. Magnetic resonance imaging as a clue to successful diagnosis of renal tuberculosis: A case report. Cases J 2009;2:8879.
  • 59 Hecht EM, Israel GM, Krinsky GA, Hahn WY, Kim DC, Belitskaya-Levy I, et al. Renal masses: Quantitative analysis of enhancement with signal intensity measurements versus qualitative analysis of enhancement with image subtraction for diagnosing malignancy at MR imaging. Radiology 2004;232:373-8.
  • 60 Holland AE, Goldfarb JW, Edelman RR. Diaphragmatic and cardiac motion during suspended breathing: Preliminary experience and implications for breath-hold MR imaging. Radiology 1998;209:483-9.
  • 61 Katsuda T, Kuroda C, Fujita M. Reducing misregistration of mask image in hepatic DSA. Radiol Technol 1997;68:487-90.
  • 62 Fan ZM, Zeng QY, Huo JW, Bai L, Liu ZS, Luo LF, et al. Macronodular multi-organs tuberculoma: CT and MR appearances. J Gastroenterol 1998;33:285-8.
  • 63 Gupta RK, Pandey R, Khan EM, Mittal P, Gujral RB, Chhabra DK. Intracranial tuberculomas: MRI signal intensity correlation with histopathology and localised proton spectroscopy. Magn Reson Imaging 1993;11:443-9.
  • 64 Verswijvel G, Janssens F, Vandevenne J, Stessens L, Meylaerts P, Palmers Y. Renal macronodular tuberculoma: CT and MR findings in an asymptomatic patient. JBR-BTR 2002;85:203-5.
  • 65 Togao O, Doi S, Kuro-o M, Masaki T, Yorioka N, Takahashi M. Assessment of renal fibrosis with diffusion-weighted MR imaging: Study with murine model of unilateral ureteral obstruction. Radiology 2010;255:772-80.
  • 66 Thoeny HC, Grenier N. Science to practice: Can diffusion-weighted MR imaging findings be used as biomarkers to monitor the progression of renal fibrosis? Radiology 2010;255:667-8.
  • 67 Ries BG, Kauczor HU, Konerding MA, Thelen M. Diagnosis of acute lung embolism with spiral CT and 3D reconstruction. Development of an animal model and technical probe in an ex-vivo experiment. Radiologe 2001;41:187-94.
  • 68 Cova M, Squillaci E, Stacul F, Manenti G, Gava S, Simonetti G, et al. Diffusion-weighted MRI in the evaluation of renal lesions: Preliminary results. Br J Radiol 2004;77:851-7.
  • 69 Brennan RE, Pollack HM. Nonvisualized ("phantom") renal calyx: Causes and radiological approach to diagnosis. Urol Radiol 1979;1:17-23.
  • 70 Elkin M. Radiology of the urinary system. Boston: Little Brown and Company; 1980. p. 148-152.
  • 71 Wise GJ. Urinary tuberculosis: Modern issues. Curr Urol Rep 2009;10:313-8.
  • 72 Khaira A, Bagchi S, Sharma A, Mukund A, Mahajan S, Bhowmik D, et al. Renal allograft tuberculosis: Report of three cases and review of literature. Clin Exp Nephrol 2009;13:392-6.
  • 73 Dowdy L, Ramgopal M, Hoffman T, Ciancio G, Burke G, Roth D, et al. Genitourinary tuberculosis after renal transplantation: Report of 3 cases and review. Clin Infect Dis 2001;32:662-6.
  • 74 Mourad G, Soulillou JP, Chong G, Pouliquen M, Hourmant M, Mion C. Transmission of Mycobacterium tuberculosis with renal allografts. Nephron 1985;41:82-5.
  • 75 Altintepe L, Tonbul HZ, Ozbey I, Guney I, Odabas AR, Cetinkaya R, et al. Urinary tuberculosis: Ten years′ experience. Ren Fail 2005;27:657-61.
  • 76 Zhang XF, Lv Y, Xue WJ, Wang B, Liu C, Tian PX, et al. Mycobacterium tuberculosis infection in solid organ transplant recipients: Experience from a single center in China. Transplant Proc 2008;40:1382-5.
  • 77 Nayak S, Satish R. Genitourinary tuberculosis after renal transplantation: A report of three cases with a good clinical outcome. Am J Transplant 2007;7:1862-4.
  • 78 George P, Pawar B, Calton N. Tuberculosis in a renal allograft: A successful outcome. Saudi J Kidney Dis Transpl 2008;19:790-2.
  • 79 Centers for Disease Control and Prevention (CDC). Transplantation-transmitted tuberculosis-Oklahoma and Texas, 2007. MMWR Morb Mortal Wkly Rep 2008;57:333-6.
  • 80 John GT, Shankar V, Abraham AM, Mukundan U, Thomas PP, Jacob CK. Risk factors for post-transplant tuberculosis. Kidney Int 2001;60:1148-53.
  • 81 Singh N, Paterson DL. Mycobacterium tuberculosis infection in solid-organ transplant recipients: Impact and implications for management. Clin Infect Dis 1998;27:1266-77.
  • 82 Basiri A, Moghaddam SM, Simforoosh N, Einollahi B, Hosseini M, Foirouzan A, et al. Preliminary report of a nationwide case-control study for identifying risk factors of tuberculosis following renal transplantation. Transplant Proc 2005;37:3041-4.
  • 83 Mercadal L, Foltz V, Isnard-Bagnis C, Ourahma S, Deray G. Tuberculosis after conversion from azathioprine to mycophenolate mofetil in a long-term renal transplant recipient. Transplant Proc 2005;37:4241-3.
  • 84 Walker JF, Cronin CJ, O′Neill S, McNulty J, Hanson JS. Tuberculosis affecting a cadaveric renal allograft. Clin Nephrol 1982;17:262-5.
  • 85 Alsoub H, Al Alousi FS, Haider A. Renal allograft tuberculosis: A case report. Ann Saudi Med 2002;22:346-8.
  • 86 Choi IS, Park JB, Kim SJ, Joh JW, Lee SK, Huh WS, et al. Tuberculous abscess of the graft in a renal transplant recipient after chronic rejection: Case report. Transplant Proc 2000;32:1957-8.
  • 87 Adeva Andany M, Falcón TG, Lozano IR, Bouza P, Alonso A, Valvuena L. Tuberculous interstitial nephritis of the renal graft. Nephron 1994;68:143-4.
  • 88 Gonçalves AR, Caetano MA, Paula FJ, Ianhez LE, Saldanha LB, Sabbaga E. Tuberculous interstitial granulomatous nephritis in renal transplants: Report of three cases. Transplant Proc 1992;24:1911.
  • 89 Figueiredo AA, Lucon AM, Júnior RF, Ikejiri DS, Nahas WC, Srougi M. Urogenital tuberculosis in immunocompromised patients. Int Urol Nephrol 2009;41:327-33.
  • 90 Eastwood JB, Corbishley CM, Grange JM. Tuberculosis and the kidney. J Am Soc Nephrol 2001;12:1307-14.