Soluble CD163: A novel biomarker for the susceptibility to sepsis in severe burn injuries

Andrzej Piatkowski; Gerrit Grieb; Rittuparna Das; Ahmet Bozkurt; Dietmar Ulrich; Norbert Pallua

doi:10.4103/0970-0358.81454

Indian Journal of Plastic Surgery, Inhaltsverzeichnis

CC BY-NC-ND 4.0 · Indian J Plast Surg 2011; 44(01): 118-124
DOI: 10.4103/0970-0358.81454

Original Article

Association of Plastic Surgeons of India

Soluble CD163: A novel biomarker for the susceptibility to sepsis in severe burn injuries

Andrzej Piatkowski

Department of Plastic Surgery and Hand Surgery, Burn Unit of the RWTH University Hospital in Aachen, Germany

,

Gerrit Grieb

Department of Plastic Surgery and Hand Surgery, Burn Unit of the RWTH University Hospital in Aachen, Germany

,

Rittuparna Das

¹Department of Internal Medicine, Section of Infectious Disease, The Anlyan Center, 300 Cedar Street, Yale School of Medicine, New Haven, CT 06520, USA

,

Ahmet Bozkurt

Department of Plastic Surgery and Hand Surgery, Burn Unit of the RWTH University Hospital in Aachen, Germany

,

Dietmar Ulrich

Department of Plastic Surgery and Hand Surgery, Burn Unit of the RWTH University Hospital in Aachen, Germany

,

Norbert Pallua

Department of Plastic Surgery and Hand Surgery, Burn Unit of the RWTH University Hospital in Aachen, Germany

› Institutsangaben

Abstract

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ABSTRACT

Objective: Soluble CD163 (sCD163) has been previously shown to play a role in inflammatory and infectious diseases. This study, for the first time, investigates the characteristics and potential values of sCD163 in burn patients. A first look is taken on the changes of sCD163 levels in burn patients by comparing predefined subgroups at single time points. Materials and Methods: Serum samples of 18 patients with burn injuries were collected for biochemical analysis at the time of admission and in a chronological sequence of 12, 24, 48 and 120 h after the injury and were matched to clinical parameters. Statistical analysis was performed using the Mann-Whitney test, Wilcoxon signed rank and Pearson bivariate correlation. Results: Patients with sepsis showed a significant increase of sCD163 levels. sCD163 was correlated with leukocytes (P=0.035) over the time course of 120 h. Patients characterized by a burn size exceeding 25% of the total body surface area (TBSA) showed a significant increase of sCD163 between 12 and 48 h after burn injury (P=0.038). Conclusions: The first view on the characteristics of sCD163 in the serum of burn patients points out that sCD163 seems to be an early indicator for the susceptibility to sepsis. Furthermore, the changes in sCD163 serum levels within the first hours after burn trauma have great potential for early prediction of organ failure after burn injury.

KEY WORDS

Inflammation - immune response - organ failure - serum marker - sepsis

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Referenzen

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