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DOI: 10.4103/0970-0358.101322
Skin substitutes: An Indian perspective
Publication History
Publication Date:
27 November 2019 (online)

ABSTRACT
There have been numerous alternatives developed to replace skin. These can either be permanent substitutes or temporary substitutes, which need to be replaced later by autologous grafts. These have been tried in recent times as an attempt to reduce the need or in the case of permanent substitutes ,altogether replace autologous skin grafts. However till date no ideal skin substitute has been developed. Various factors have to be considered while choosing one of these substitutes. In a developing country like India awareness and availability of these skin substitutes is not adequate considering the volume of cases that require this modality of treatment. Also there are skin substitutes developed in our country that need to be highlighted. This article is an attempt to review the vast array of skin substitutes that have been developed and consider their utility and feasibility for developing countries.
- 1 Kumar P. Classification of skin substitutes. Burns 2008;34:148-9.
- 2 Colocho G, Graham WP 3rd, Greene AE, Matheson DW, Lynch D. Human amniotic membrane as a physiologic wound dressing. Arch Surg 1974;109:370-3.
- 3 Shores JT, Gabriel A, Gupta S. Skin substitutes and alternatives: A review. Adv Skin Wound Care 2007;20:493-508.
- 4 Halim AS, Khoo TL, Yussof SJ. Biologic and synthetic skin substitutes: An overview. Indian J Plast Surg 2010; 43(Suppl):S23-8.
- 5 Pigeon J. Treatment of second-degree burns with amniotic membranes. Can Med Assoc J 1960;83:844-5.
- 6 Nakamura T, Yoshitani M, Rigby H, Fullwood NJ, Ito W, Inatomi T. Sterilized, freeze-dried amniotic membrane: A useful substrate for ocular surface reconstruction. Invest Ophthalmol Vis Sci 2004;45:93-9.
- 7 Hanumanthappa MB, Gopinathan S, Rithin S, Rai DD, Shetty G, Shetty K, et al. Amniotic membrane dressing versus normal saline dressing in non-healing lower limb ulcers: A prospective comparative study at a Teaching Hospital. Int J Biol Med Res 2012;3:1616-20.
- 8 Keswani MH, Patil AR. The boiled potatopeel as a burn wound dressing: A preliminary report. Burns 1985;11:220-4.
- 9 Gore MA, Akolekar D. Evaluation of banana leaf dressing for partial thickness burn wounds. Burns 2003;29:487-92.
- 10 Wainwright DJ. Use of an acellular allograft dermal matrix (Alloderm) in the management of full-thickness burns. Burns 1995;21:243-8.
- 11 Lukish JR, Eichelberger MR, Newman KD, Pao M, Nobuhara K, Keating M, et al. The use of a bioactive skin substitute decreases length of stay for pediatric burn patients. J Pediatr Surg 2001;36:1118-21.
- 12 Trent JF, Kirsner RS. Tissue engineered skin: Apligraf, a bi-layered living skin equivalent. Int J Clin Pract 1998;52:408-13.
- 13 Waymack P, Duff RG, Sabolinski M. The effect of a tissue engineered bilayered living skin analog, over meshed split-thickness autografts on the healing of excised burn wounds. The Apligraf Burn Study Group. Burns 2000;26:609-19.
- 14 Haynes B. The history of burn care. In: Bosivich J, editor. The Art and Science of Burn Care. Rockville, MD: Aspen Publication; 1987. p. 3.
- 15 Piccola N. Use of frog skin as a temporary biologic dressing. Proc Am Burn Assoc 1992];24.
- 16 Chiu T, Burd A. "Xenograft" dressing in the treatment of burns. Clin Dermatol 2005;23:419-23.
- 17 Mat Zaad AZ, Khoo TL, Dorai AA, Halim AS. The versatility of a glycerol-preserved skin allograft as an adjunctive treatment to free flap reconstruction. Indian J Plast Surg 2009;42:95-9.
- 18 Khoo TL, Halim AS, Saad AZ, Dorai AA. The application of glycerol-preserved skin allograft in the treatment of burn injuries: An analysis based on indications. Burns 2010;36:897-904.
- 19 Gore MA, De AS. Deceased donor skin allograft banking: Response and utilization. Indian J Plast Surg 2010;43(Suppl):S114-20.
- 20 Agarwal R, Singh AK, Dhole TN. Early experience with autologous skin culture for wound therapy. Indian J Plast Surg 2007;40:104-6.
- 21 Wright KA, Nadire KB, Busto P, Tubo R, McPherson JM, Wentworth BM. Alternative delivery of keratinocytes using a polyurethane membrane and the implications for its use in the treatment of full-thickness burn injury. Burns 1998;24:7-17.
- 22 Lobmann R, Pittasch D, Muhlen I, Lehnert H. Autologous human keratinocytes cultured on membranes composed of benzyl ester of hyaluronic acid for grafting in nonhealing diabetic foot lesions: A pilot study. J Diabetes Complications 2003;17:199-204.
- 23 Harriger MD, Warden GD, Greenhalgh DG, Kagan RJ, Boyce ST. Pigmentation and microanatomy of skin regenerated from composite grafts of cultured cells and biopolymers applied to full-thickness burn wounds. Transplantation 1995;59:702-7.
- 24 Grzesiak JJ, Pierschbacher MD, Amodeo MF, Malaney TI, Glass JR. Enhancement of cell interactions with collagen/glycosaminoglycan matrices by RGD derivatization. Biomaterials 1997;18:1625-32.
- 25 Stern R, McPherson M, Longaker MT. Histologic study of artificial skin used in the treatment of full-thickness thermal injury. J Burn Care Rehabil 1990;11:7-13.
- 26 Jeschke MG, Rose C, Angele P, Fuchtmeier B, Nerlich MN, Bolder U. Development of new reconstructive techniques: use of Integra in combination with fibrin glue and negative-pressure therapy for reconstruction of acute and chronic wounds. Plast Reconstr Surg 2004;113:525-30.
- 27 Banes AJ, Compton DW, Bornhoeft J, Hicks H, Link GW, Bevin AG, et al. Biologic, biosynthetic, and synthetic dressings as temporary wound covers: A biochemical comparison. J Burn Care Rehabil 1986;7:96-104.
- 28 McHugh TP, Robson MC, Heggers JP, Phillips LG, Smith DJ Jr, McCollum MC. Therapeutic efficacy of Biobrane in partial- and full-thickness thermal injury. Surgery 1986;100:661-4.
- 29 Sundaramurthi D, Vasanthan KS, Kuppan P, Krishnan UM, Sethuraman S. Electrospun nanostructured chitosan-poly(vinyl alcohol) scaffolds: A biomimetic extracellular matrix as dermal substitute. Biomed Mater 2012;7:045005.
- 30 Trottier V, Marceau-Fortier G, Germain L, Vincent C, Fradette J. Using human adipose-derived stem/stromal cells for the production of new skin substitutes. Stem Cells 2008;26:2713-23.
- 31 Li Y, Tredget EE, Ghaffari A, Lin X, Kilani RT, Ghahary A. Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute. J Invest Dermatol 2006;126:128-36.