An update review of stem cell applications in burns and wound care

ABSTRACT

The ultimate goal of the treatment of cutaneous burns and wounds is to restore the damaged skin both structurally and functionally to its original state. Recent research advances have shown the great potential of stem cells in improving the rate and quality of wound healing and regenerating the skin and its appendages. Stem cell-based therapeutic strategies offer new prospects in the medical technology for burns and wounds care. This review seeks to give an updated overview of the applications of stem cell therapy in burns and wound management since our previous review of the "stem cell strategies in burns care".

KEY WORDS

Burns - stem cell - wound

• 1 Burd A, Ahmed K, Lam S, Ayyappan T, Huang L. Stem cell strategies in burns care. Burns 2007;33:282-91.
• 2 Chen M, Przyborowski M, Berthiaume F. Stem cell for skin tissue engineering and wound healing. Crit Rev Biomed Eng 2009;37:399-421.
• 3 Christiano AM. Epithelial stem cells: Stepping out of their niche. Cell 2004;118:530-2.
• 4 Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, et al. A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells 2008;26:163-72.
• 5 Petschnik AE, Klatte JE, Evers LH, Kruse C, Paus R, Danner S. Phenotypic indications that human sweat glands are a rich source of nestin-positive stem cell populations. Br J Dermatol 2010;162:380-3.
• 6 Zou Z, Zhang Y, Hao L, Wang F, Liu D, Su Y, et al. More insight into mesenchymal stem cells and their effects inside the body. Expert Opin Biol Ther 2010;10:215-30.
• 7 Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-72.
• 8 Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007;1:39-49.
• 9 González F, Boué S, Izpisúa Belmonte JC. Methods for making induced pluripotent stem cells: Reprogramming à la carte. Nat Rev Genet 2011;12:231-42.
• 10 Guenou H, Nissan X, Larcher F, Feteira J, Lemaitre G, Saidani M, et al. Human embryonic stem-cell derivatives for full reconstruction of the pluristratified epidermis: A preclinical study. Lancet 2009;374:1745-53.
• 11 Itoh M, Kiuru M, Cairo MS, Christiano AM. Generation of keratinocytes from normal and recessive dystrophic epidermolysis bullosa-induced pluripotent stem cells. Proc Natl Acad Sci U S A 2011;108:8797-802.
• 12 Butler KL, Goverman J, Ma H, Fischman A, Yu YM, Bilodeau M, et al. Stem cells and burns: Review and therapeutic implications. J Burn Care Res 2010;31:874-81.
• 13 Wood FM, Kolybaba ML, Allen P. The use of cultured epithelia autograft in the treatment of major burn wounds: Eleven years of clinical experience. Burns 2006;32:538-44.
• 14 Chester DL, Balderson DS, Papini RP. A review of keratinocyte delivery to the wound bed. J Burn Care Rehabil 2004;25:266-75.
• 15 Wood FM, Kolybaba ML, Allen P. The use of cultured epithelial autograft in the treatment of major burn injuries: A critical review of the literature. Burns 2006;32:395-401.
• 16 Pellegrini G, Ranno R, Stracuzzi G, Bondanza S, Guerra L, Zambruno G, et al. The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin. Transplantation 1999;68:868-79.
• 17 Rheinwald JG, Green H. Serial cultivation of strains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells. Cell 1975;6:331-43.
• 18 Amemiya T, Nakamura T, Yamamoto T, Kinoshita S, Kanamura N. Immunohistochemical study of oral epithelial sheets cultured on amniotic membrane for oral mucosal reconstruction. Biomed Mater Eng 2010;20:37-45.
• 19 Takagi R, Yamato M, Murakami D, Kondo M, Yang J, Ohki T, et al. Preparation of keratinocyte culture medium for the clinical applications of regenerative medicine. J Tissue Eng Regen Med 2011;5:e63-73.
• 20 Zhu N, Warner RM, Simpson C, Glover M, Hernon CA, Kelly J, et al. Treatment of burns and chronic wounds using a new cell transfer dressing for delivery ofautologous keratinocytes. Eur J Plast Surg 2005;28:319-30.
• 21 Currie LJ, Martin R, Sharpe JR, James SE. A comparison of keratinocyte cell sprays with and without fibrin glue. Burns 2003;29:677-85.
• 22 Ronfard V, Rives JM, Neveux Y, Carsin H, Barrandon Y. Long-term regeneration of human epidermis on third degree burns transplanted with autologous cultured epithelium grown on a fibrin matrix. Transplantation 2000;70:1588-98.
• 23 Kaiser HW, Stark GB, Kopp J, Balcerkiewicz A, Spilker G, Kreysel HW. Cultured autologous keratinocytes in fibrin glue suspension, exclusively and combined with STS-allograft (preliminary clinical and histological report of a new technique). Burns 1994;20:23-9.
• 24 Loss M, Wedler V, Künzi W, Meuli-Simmen C, Meyer VE. Artificial skin, split-thickness autograft and cultured autologous keratinocytes combined to treat a severe burn injury of 93% of TBSA. Burns 2000;26:644-52.
• 25 Yim H, Cho YS, Seo CH, Lee BC, Ko JH, Kim D, et al. The use of AlloDerm on major burn patients: AlloDerm prevents post-burn joint contracture. Burns 2010;36:322-8.
• 26 Rasulov MF, Vasilchenkov AV, Onishchenko NA, Krasheninnikov ME, Kravchenko VI, Gorshenin TL, et al. First experience of the use bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns. Bull Exp Biol Med 2005;139:141-4.
• 27 Vojtassák J, Danisovic L, Kubes M, Bakos D, Jarábek L, Ulicná M, et al. Autologous biograft and mesenchymal stem cells in treatment of the diabetic foot. Neuro Endocrinol Lett 2006;27 Suppl 2:134-7.
• 28 Falanga V, Iwamoto S, Chartier M, Yufit T, Butmarc J, Kouttab N, et al. Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds. Tissue Eng 2007;13:1299-312.
• 29 Dieckmann C, Renner R, Milkova L, Simon JC. Regenerative medicine in dermatology: Biomaterials, tissue engineering, stem cells, gene transfer and beyond. Exp Dermatol 2010;19:697-706.
• 30 Ghannam S, Bouffi C, Djouad F, Jorgensen C, Noël D. Immunosuppression by mesenchymal stem cells: Mechanisms and clinical applications. Stem Cell Res Ther 2010;1:2.
• 31 Ravari H, Hamidi-Almadari D, Salimifar M, Bonakdaran S, Parizadeh MR, Koliakos G. Treatment of non-healing wounds with autologous bone marrow cells, platelets, fibrin glue and collagen matrix. Cytotherapy 2011;13:705-11.
• 32 Bey E, Prat M, Duhamel P, Benderitter M, Brachet M, Trompier F, et al. Emerging therapy for improving wound repair of severe radiation burns using local bone marrow-derived stem cell administrations. Wound Repair Regen 2010;18:50-8.
• 33 Benderitter M, Gourmelon P, Bey E, Chapel A, Clairand I, Prat M, et al. New emerging concepts in the medical management of local radiation injury. Health Phys 2010;98:851-7.
• 34 Ichioka S, Kouraba S, Sekiya N, Ohura N, Nakatsuka T. Bone marrow-impregnated collagen matrix for wound healing: Experimental evaluation in a microcirculatory model of angiogenesis, and clinical experience. Br J Plast Surg 2005;58:1124-30.
• 35 Arno A, Smith AH, Blit PH, Shehab MA, Gauglitz GG, Jeschke MG. Stem cell therapy: A new treatment for burns? Pharmaceuticals 2011;4:1355-80.
• 36 Li H, Fu X, Ouyang Y, Cai C, Wang J, Sun T. Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages. Cell Tissue Res 2006;326:725-36.
• 37 Sheng Z, Fu X, Cai S, Lei Y, Sun T, Bai X, et al. Regeneration of functional sweat gland-like structures by transplanted differentiated bone marrow mesenchymal stem cells. Wound Repair Regen 2009;17:427-35.
• 38 Huang S, Lu G, Wu Y, Jirigala E, Xu Y, Ma K, et al. Mesenchymal stem cells delivered in a microsphere-based engineered skin contribute to cutaneous wound healing and sweat gland repair. J Dermatol Sci 2012;66:29-36.
• 39 Yoshimura K, Shigeura T, Matsumoto D, Sato T, Takaki Y, Aiba-Kojima E, et al. Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. J Cell Physiol 2006;208:64-76.
• 40 Yoshimura K, Sato K, Aoi N, Kurita M, Hirohi T, Harii K. Cell-assisted lipotrasfer for cosmetic breast augmentation: Supportive use of adipose-derived stem/stromal cells. Aesthetic Plast Surg 2008;32:48-55.
• 41 Wilson A, Butler PE, Seifalian AM. Adipose-derived stem cells for clinical applications: A review. Cell Prolif 2011:44:86-98.
• 42 Trottier V, Marceau-Fortier G, Germain L, Vincent C, Fradette J. IFATS collection: Using human adipose-derived stem/stromal cells for the production of new skin substitutes. Stem Cells 2008;26:2713-23.
• 43 Altman AM, Yan Y, Matthias N, Bai X, Rios C, Mathur AB, et al. IFATS collection: Human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model. Stem Cells 2009;27:250-8.
• 44 Nambu M, Kishimoto S, Nakamura S, Mizuno H, Yanagibayashi S, Yamamoto N, et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissue-derived stromal cells combined with atelocollagen matrix. Ann Plast Surg 2009;62:317-21.
• 45 Branski LK, Gauglitz GG, Herndon DN, Jeschke MG. A review of gene and stem cell therapy in cutaneous wound healing. Burns 2009;35:171-80.
• 46 Kamolz LP, Kolbus A, Wick N, Mazal PR, Eisenbock B, Burjak S, et al. Cultured human epithelium: Human umbilical cord blood stem cells differentiate into keratinocytes under in vitro conditions. Burns 2006;32:16-9.
• 47 Luo G, Cheng W, He W, Wang X, Tan J, Fitzgerald M, et al. Promotion of cutaneous wound healing by local application of mesenchymal stem cells derived from human umbilical cord blood. Wound Repair Regen 2010;18:506-13.
• 48 Mortier L, Delesalle F, Formstecher P, Polakowska R. Human umbilical cord blood cells form epidermis in the skin equivalent model. Exp Dermatol 2010;19:929-30.
• 49 Can A, Karahuseyinoglu S. Concise review: Human umbilical cord stroma with regard to the source of fetus-derived stem cells. Stem Cells 2007;25:2886-95.
• 50 Huang L, Wong YP, Gu H, Cai YJ, Ho Y, Wang CC, et al. Stem cell-like properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy 2011;13:145-55.
• 51 Musina RA, Bekchanova ES, Belyavskii AV, Sukhikh GT. Differentiation potential of mesenchymal stem cells of different origin. Bull Exp Biol Med 2006;141:147-51.
• 52 Li G, Zhang XA, Wang H, Wang X, Meng CL, Chan CY, et al. Comparative proteomic analysis of mesenchymal stem cells derived from human bone marrow, umbilical cord, and placenta: Implication in the migration. Proteomics 2009;9:20-30.
• 53 Kita K, Gauglitz GG, Phan TT, Herndon DN, Jeschke MG. Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane. Stem Cells Dev 2010;19:491-502.
• 54 La Rocca G. The promises of Wharton′s jelly mesenchymal stem cells for tissue repair and regeneration. Open Tissue Eng Regen Med J 2011;4:3-5.
• 55 Mizoguchi M, Ikeda S, Suga Y, Ogawa H. Expression of cytokeratins and cornified cell envelope-associated proteins in umbilical cord epithelium: A comparative study of the umbilical cord, amniotic epithelia and fetal skin. J Invest Dermatol 2000;115:133-4.
• 56 Ruetze M, Gallinat S, Lim IJ, Chow E, Phan TT, Staeb F, et al. Common features of umbilical cord epithelial cells and epidermal keratinocytes. J Dermatol Sci 2008;50:227-31.
• 57 Sanmano B, Mizoguchi M, Suga Y, Ikeda S, Ogawa H. Engraftment of umbilical cord epithelial cells in athymic mice: In an attempt to improve reconstructed skin equivalents used as epithelial composite. J Dermatol Sci 2005;37:29-39.
• 58 Reza HM, Ng BY, Gimeno FL, Phan TT, Ang LP. Umbilical cord lining stem cells as a novel and promising source for ocular surface regeneration. Stem Cell Rev 2011;7:935-47.
• 59 Piatkowski A, Gröger A, Pantel M, Bozkurt A, Fuchs PC, Pallua N. The extent of thermal injury affects fractions of mononuclear cells. Burns 2009;35:256-63.
• 60 Bhattacharya N. A study of placental umbilical cord whole blood transfusion in 72 patients with anemia and emaciation in the background of cancer. Eur J Gynaecol Oncol. 2006;27:155-61.
• 61 Bhattacharya N. Placental umbilical cord blood transfusion: A novel method of treatment of patients with malaria in the background of anemia. Clin Exp Obstet Gynecol 2006;33:39-43.
• 62 Chaudhuri A, Hollands P, Bhattacharya N. Placental umbilical cord blood transfusion in acute ischaemic stroke. Med Hypotheses 2007;69:1267-71.