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CC BY 4.0 · AIMS Genet 2015; 02(01): 001-012
DOI: 10.3934/genet.2015.1.1
Review

Drosophila as a model for chromosomal instability

Dawei Liu
1   School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide S.A. 5006, Australia
,
Zeeshan Shaukat
1   School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide S.A. 5006, Australia
,
Rashid Hussain
1   School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide S.A. 5006, Australia
,
Mahwish Khan
1   School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide S.A. 5006, Australia
,
Stephen L. Gregory
1   School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide S.A. 5006, Australia
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Abstract

Chromosomal instability (CIN) is a common feature of tumours that leads to increased genetic diversity in the tumour and poor clinical outcomes. There is considerable interest in understanding how CIN comes about and how its contribution to drug resistance and metastasis might be counteracted. In the last decade a number of CIN model systems have been developed in Drosophila that offer unique benefits both in understanding the development of CIN in a live animal as well as giving the potential to do genome wide screens for therapeutic candidate genes. This review outlines the mechanisms used in several Drosophila CIN model systems and summarizes some significant outcomes and opportunities that they have produced.

Keywords

aneuploidy - cell cycle - checkpoint - chromosomal instability - DNA damage - Drosophila - JNK - metabolism - ROS


Publikationsverlauf

Eingereicht: 30. Oktober 2014

Angenommen: 16. Dezember 2014

Artikel online veröffentlicht:
10. Mai 2021

© 2015. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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