J Am Acad Audiol 2016; 27(08): 661-668
DOI: 10.3766/jaaa.15106
American Academy of Audiology. All rights reserved. (2016) American Academy of Audiology

Manganese and Lipoflavonoid Plus® to Treat Tinnitus: A Randomized Controlled Trial

Eveling Rojas-Roncancio
Richard Tyler
Hyung-Jin Jun
Tang-Chuan Wang
Haihong Ji
Claudia Coelho
Shelley Witt
Marlan R. Hansen
Bruce J. Gantz
Further Information

Publication History

Publication Date:
06 August 2020 (online)

Background: Several tinnitus sufferers suggest that manganese has been helpful with their tinnitus.

Purpose: We tested this in a controlled experiment where participants were committed to taking manganese and Lipoflavonoid Plus® to treat their tinnitus.

Research Design: Randomized controlled trial.

Study Sample: 40 participants were randomized to receive both manganese and Lipoflavonoid Plus® for 6 months, or Lipoflavonoid Plus® only (as the control).

Data Collection and Analysis: Pre- and postmeasures were obtained with the Tinnitus Handicap Questionnaire, Tinnitus Primary Functions Questionnaire, and tinnitus loudness and annoyance ratings. An audiologist performed the audiogram, the tinnitus loudness match, and minimal masking level.

Results: Twelve participants were dropped out of the study because of the side effects or were lost to follow-up. In the manganese group, 1 participant (out of 12) showed a decrease in the questionnaires, and another showed a decrease in the loudness and annoyance ratings. No participants from the control group (total 16) showed a decrease in the questionnaires ratings. Two participants in the control group reported a loudness decrement and one reported an annoyance decrement.

Conclusions: We were not able to conclude that either manganese or Lipoflavonoid Plus® is an effective treatment for tinnitus.