Vet Comp Orthop Traumatol 2013; 26(04): 251-259
DOI: 10.3415/VCOT-12-05-0065
Review Article
Schattauer GmbH

A review of local antibiotic implants and applications to veterinary orthopaedic surgery

G. Hayes
1   University of Guelph, Department of Clinical Studies, Guelph, Ontario, Canada
,
N. Moens
1   University of Guelph, Department of Clinical Studies, Guelph, Ontario, Canada
,
T. Gibson
1   University of Guelph, Department of Clinical Studies, Guelph, Ontario, Canada
› Author Affiliations
Further Information

Publication History

Received 15 May 2012

Accepted 27 January 2013

Publication Date:
19 December 2017 (online)

Summary

In the face of increasing incidence of multidrug resistant implant infections, local antibiotic modalities are receiving increased attention for both infection prophylaxis and treatment. Local antibiotic therapy that achieves very high antibiotic drug concentrations at the site of the implant may represent an avenue for treatment of biofilmforming bacterial pathogens. Randomized controlled trials in human patients have demonstrated an infection risk reduction when antibiotic-impregnated cement is used for infection prophylaxis in implanted joint prostheses, and when a gentamicin-impregnated collagen sponge is used for infection prophylaxis in midline sternotomy. The other modalities discussed have for the most part yet to be evaluated in randomized controlled trials in veterinary or human patients. In general, the in vivo pharmacokinetics and appropriate dosing profiles for local antibiotic modalities have yet to be elucidated. Toxicity is possible, and attention to the dose applied is warranted.