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Vet Comp Orthop Traumatol 2010; 23(06): 385-392
DOI: 10.3415/VCOT-10-01-0017
DOI: 10.3415/VCOT-10-01-0017
Review Article
Non-steroidal anti-inflammatory drugs inhibit bone healing: A review
Further Information
Publication History
Received:
31 January 2010
Accepted:
23 June 2010
Publication Date:
19 December 2017 (online)
Summary
The ability of non-steroidal anti-inflammatory drugs (NSAID) to inhibit bone healing has been established in experimental animal models using mice, rats, and rabbits. The mechanism of action is largely unknown but stems from prostaglandin inhibition and is likely multifactorial. In human medicine NSAID are known to prevent heterotopic ossification, however the clinical importance of their effects on bone healing remains controversial. Although a small handful of reports suggest that NSAID suppress bone healing in dogs and horses, there is little published information to direct veterinary practice in domestic species.
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