Thieme E-Journals - Journal of Pediatric Neuroradiology / Abstract
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Journal of Pediatric Neuroradiology 2012; 01(02): 117-120
DOI: 10.3233/PNR-2012-017
Georg Thieme Verlag KG Stuttgart – New York

Multimodal neuroimaging transcends time in thrombolysis for pediatric stroke

Authors

  • Waimei Amy Tai

    a   Department of Neurology, University of Southern California, Los Angeles, CA, USA

  • Nerses Sanossian

    a   Department of Neurology, University of Southern California, Los Angeles, CA, USA

  • Arthur Partikian

    a   Department of Neurology, University of Southern California, Los Angeles, CA, USA
    b   Department of Pediatrics, University of Southern California, Los Angeles, CA, USA

  • Monique Mogensen

    c   Department of Radiology, University of Southern California, Los Angeles, CA, USA

  • Jesse Jones

    c   Department of Radiology, University of Southern California, Los Angeles, CA, USA

  • David S. Liebeskind

    d   University of California, Los Angeles Stroke Center, University of California Los Angeles, Los Angeles, CA, USA

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Abstract

Pediatric stroke is particularly challenging because of its variable presentation and relative rarity. Diagnosis of pediatric stroke is often delayed while other diagnoses are considered, unfortunately leading to a loss of therapeutic opportunity. Recent research advances in adult stroke such as multimodal imaging and a clinical trial showing benefits in extending the therapeutic window for thrombolytics are likely to have important implications in pediatric stroke. We describe the case of a 13-year-old boy presenting with acute stroke where multimodal magnetic resonance imaging with perfusion and permeability images allowed safe treatment with thrombolysis outside the standard treatment time window.

Keywords

Multimodal MRI - thrombolysis - stroke - children