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Journal of Pediatric Neuroradiology 2012; 01(02): 117-120
DOI: 10.3233/PNR-2012-017
Georg Thieme Verlag KG Stuttgart – New York

Multimodal neuroimaging transcends time in thrombolysis for pediatric stroke

Waimei Amy Tai
a   Department of Neurology, University of Southern California, Los Angeles, CA, USA
,
Nerses Sanossian
a   Department of Neurology, University of Southern California, Los Angeles, CA, USA
,
Arthur Partikian
a   Department of Neurology, University of Southern California, Los Angeles, CA, USA
b   Department of Pediatrics, University of Southern California, Los Angeles, CA, USA
,
Monique Mogensen
c   Department of Radiology, University of Southern California, Los Angeles, CA, USA
,
Jesse Jones
c   Department of Radiology, University of Southern California, Los Angeles, CA, USA
,
David S. Liebeskind
d   University of California, Los Angeles Stroke Center, University of California Los Angeles, Los Angeles, CA, USA
› Author Affiliations
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Publication History

10 January 2011

04 March 2011

Publication Date:
28 July 2015 (online)

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Abstract

Pediatric stroke is particularly challenging because of its variable presentation and relative rarity. Diagnosis of pediatric stroke is often delayed while other diagnoses are considered, unfortunately leading to a loss of therapeutic opportunity. Recent research advances in adult stroke such as multimodal imaging and a clinical trial showing benefits in extending the therapeutic window for thrombolytics are likely to have important implications in pediatric stroke. We describe the case of a 13-year-old boy presenting with acute stroke where multimodal magnetic resonance imaging with perfusion and permeability images allowed safe treatment with thrombolysis outside the standard treatment time window.

Keywords

Multimodal MRI - thrombolysis - stroke - children