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J Pediatr Intensive Care 2014; 03(03): 133-146
DOI: 10.3233/PIC-14095
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Non-infectious pulmonary complications of hematopoietic stem cell transplantation

Courtney Rowan
a   Department of Pediatrics, Section of Critical Care, Indiana University School of Medicine, Indianapolis, IN, USA
,
Orkun Baloglu
b   Department of Pediatrics, Division of Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
,
Jennifer McArthur
b   Department of Pediatrics, Division of Critical Care Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
› Author Affiliations
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Publication History

05 July 2014

01 October 2014

Publication Date:
28 July 2015 (online)

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Abstract

Noninfectious pulmonary complications of hematopoietic stem cell transplant are currently more prevalent than infectious complications. Unfortunately, the pathophysiology basis is not completely understood. However, there is a string association with graft-versus-host disease for many of them. Therefore, an important component of their pathophysiology is likely an allo-immune response. There is much research that needs to be conducted to improve the less than optimal outcomes for these disorders.

Keywords

Hematopoietic cell transplant - pulmonary complications - graft versus host disease