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J Pediatr Intensive Care 2014; 03(03): 103-113
DOI: 10.3233/PIC-14094
Review Article
Georg Thieme Verlag KG Stuttgart – New York

A review of graft versus host disease

Jerelyn R. Moffet
a   Department of Pediatrics, Pediatric Blood and Marrow Transplant Division, Duke University, Durham, NC, USA
,
Lauren A. Stafford
a   Department of Pediatrics, Pediatric Blood and Marrow Transplant Division, Duke University, Durham, NC, USA
,
Andre R. Stokhuyzen
a   Department of Pediatrics, Pediatric Blood and Marrow Transplant Division, Duke University, Durham, NC, USA
,
Erika D. Summers
a   Department of Pediatrics, Pediatric Blood and Marrow Transplant Division, Duke University, Durham, NC, USA
› Author Affiliations
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Further Information

Publication History

05 July 2014

27 September 2014

Publication Date:
28 July 2015 (online)

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Abstract

Children undergoing hematopoietic stem cell transplant often require intensive care support due to their underlying disease, sepsis, infection, hemorrhage, respiratory failure and organ dysfunction. The majority of children requiring intensive care support have an allogeneic donor. These children carry a higher likelihood of graft versus host disease complicating their medical management. Understanding the process of graft versus host disease is important in the shared care of these children between pediatric intensive care physicians and the bone marrow transplant team.

Keywords

Allogeneic hematopoietic stem cell transplant - graft versus host disease - pediatrics