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J Pediatr Genet 2012; 01(03): 175-180
DOI: 10.3233/PGE-2012-027
Georg Thieme Verlag KG Stuttgart – New York

Cytogenetic analysis in a large series of children with non-syndromic mental retardation

Authors

  • Inesse Ben Abdallah Bouhjar

    a   Department of Cytogenetic and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
    e   Common Service Units for Research in Genetics, Faculty of Medicine, Sousse, Tunisia

  • Abir Gmidène

    a   Department of Cytogenetic and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia

  • Soumaya Mougou-Zrelli

    a   Department of Cytogenetic and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
    e   Common Service Units for Research in Genetics, Faculty of Medicine, Sousse, Tunisia

  • Hanene Hannachi

    a   Department of Cytogenetic and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
    e   Common Service Units for Research in Genetics, Faculty of Medicine, Sousse, Tunisia

  • Najla Soyah

    b   Department of Pediatrics, Farhat Hached University Teaching Hospital, Sousse, Tunisia

  • Naoufel Gadour

    c   Department of Psychiatric, Fatouma Bourguiba University Teaching Hospital, Monastir, Tunisia

  • Imed Harrabi

    d   Department of Epidemiology, Farhat Hached University Teaching Hospital, Sousse, Tunisia

  • Hatem Elghezal

    a   Department of Cytogenetic and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
    e   Common Service Units for Research in Genetics, Faculty of Medicine, Sousse, Tunisia

  • Ali Saad

    a   Department of Cytogenetic and Reproductive Biology, Farhat Hached University Teaching Hospital, Sousse, Tunisia
    e   Common Service Units for Research in Genetics, Faculty of Medicine, Sousse, Tunisia

Subject Editor:
Further Information

Publication History

07 December 2010

15 March 2012

Publication Date:
27 July 2015 (online)

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Abstract

Mental retardation affects 1–3% of the population. To evaluate the implication of chromosomal abnormalities in the etiology of mental retardation, 1420 patients with non-syndromic mental retardation recruited at the department of cytogenetics of Farhat Hached hospital (Sousse, Tunisia) between January 2005 and December 2009, were analyzed using standard cytogenetic techniques. Age ranged between 3 and 18 years with a median of 8 years. Chromosomal abnormalities were detected in 7.8% of patients and an increased prevalence of chromosome anomalies was observed in patients when the mental retardation is associated with a severe degree of intellectual disability, facial dysmorphic features and/or congenital malformations or epilepsy.

Keywords

Chromosomal abnormalities - congenital malformations - epilepsy - facial dysmorphism - karyotype - mental retardation