Contributions of neuroimaging to understand childhood epileptic encephalopathies

Milena Korostenskaja; Inga Griskova-Bulanova; Ki H. Lee; Po-Ching Chen; Tara S. Kleineschay; Jane C. Cook; Alex E. Schaal; Eduardo M. Castillo

doi:10.3233/PEP-14087

Journal of Pediatric Epilepsy, Table of Contents

Journal of Pediatric Epilepsy 2014; 03(03): 131-156
DOI: 10.3233/PEP-14087

Review Article

Georg Thieme Verlag KG Stuttgart – New York

Contributions of neuroimaging to understand childhood epileptic encephalopathies

Authors

Milena Korostenskaja

^aMagnetoencephalography Lab, Florida Hospital, Orlando, FL, USA

^bMilena's Functional Brain Mapping and Brain-Computer Interface Laboratory, Florida Hospital for Children, Orlando, FL, USA

^dComprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL, USA
Inga Griskova-Bulanova

^cDepartment of Neurobiology and Biophysics, Vilnius University, Vilnius, Lithuania
Ki H. Lee

^dComprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL, USA
Po-Ching Chen

^aMagnetoencephalography Lab, Florida Hospital, Orlando, FL, USA

^bMilena's Functional Brain Mapping and Brain-Computer Interface Laboratory, Florida Hospital for Children, Orlando, FL, USA

^dComprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL, USA
Tara S. Kleineschay

^aMagnetoencephalography Lab, Florida Hospital, Orlando, FL, USA

^dComprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL, USA
Jane C. Cook

^eDepartment of Radiology, Florida Hospital, Orlando, FL, USA
Alex E. Schaal

^aMagnetoencephalography Lab, Florida Hospital, Orlando, FL, USA

^dComprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL, USA
Eduardo M. Castillo

^aMagnetoencephalography Lab, Florida Hospital, Orlando, FL, USA

^dComprehensive Pediatric Epilepsy Center, Florida Hospital for Children, Orlando, FL, USA

Subject Editor:

Abstract

PDF Download

Abstract

Childhood epileptic encephalopathies (CEE) are often characterized by abnormal brain development in which epileptic electrical discharges may contribute to cognitive deficits, behavioral disturbances, or psychomotor dysfunction. Electroencephalography (EEG) is the primary diagnostic imaging tool used by care providers in order to observe the aggressive paroxysmal activity that manifests from CEE. Though EEG is an effective diagnostic tool, it provides limited insight into the etiology and pathophysiology that can be obtained through other imaging techniques. The aim of this paper is to review current neuroimaging techniques, such as intracranial EEG, magnetoencephalography, functional magnetic resonance imaging, and positron emission tomography and discuss how they complement EEG findings and contribute to our understanding of CEE. In addition, we address the value of imaging techniques in defining and predicting cognitive changes in CEE.

Keywords

Electrocorticography - EEG - encephalopathy - epilepsy - epilepsy surgery - functional MRI - neuroimaging - pediatrics - MEG - PET

PDF (1782 kb)