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Journal of Pediatric Neurology 2011; 09(01): 093-095
DOI: 10.3233/JPN-2010-0437
Georg Thieme Verlag KG Stuttgart – New York

Valproate associated hyperammonemic encephalopathy

Authors

  • Devendra Mishra

    a   Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, Delhi, India

  • Rahul Jain

    a   Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, Delhi, India

  • Monika Juneja

    a   Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, Delhi, India

  • Bisroop Chakrabarty

    a   Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, Delhi, India

Subject Editor:
Further Information

Publication History

14 September 2009

13 November 2009

Publication Date:
30 July 2015 (online)

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Abstract

Valproate associated hyperammonemic encephalopathy is a rare complication of valproate use, distinct from the more well-known valproate-induced hepatotoxicity with coma in young children, and the common finding of asymptomatic hyperammonemia associated with valproate use. We herein present a 21-month-old child with valproate associated hyperammonemic encephalopathy and discuss pertinent diagnostic and therapeutic issues for the pediatrician.

Keywords

Antiepileptic drugs - adverse drug reaction - child - encephalopathy - hyperammonemia - valproic acid