Journal of Pediatric Neurology 2009; 07(02): 117-121
DOI: 10.3233/JPN-2009-0278
Original Article
Georg Thieme Verlag KG Stuttgart – New York

Clinical effectiveness of intravenous flunitrazepam administration for prolonged seizures

Yasuhiko Kawakami
a   Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
,
Yoshiaki Matsumoto
b   College of Pharmacy, Nihon University, Funabashi, Japan
,
Kiyoshi Hashimoto
a   Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
,
Kentaro Kuwabara
a   Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
,
Kiyotaka Hirata
c   Department of Pharmacy, Nippon Medical School, Tokyo, Japan
,
Takashi Suzuki
b   College of Pharmacy, Nihon University, Funabashi, Japan
,
Takehisa Fujita
a   Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
,
Osamu Fujino
a   Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
› Author Affiliations

Subject Editor:
Further Information

Publication History

04 October 2008

20 December 2008

Publication Date:
30 July 2015 (online)

Abstract

For the treatment of prolonged seizures in children, the use of diazepam is well established. Flunitrazepam, a benzodiazepine derivative like diazepam, has also been reported to relieve prolonged seizures. In this study, the effectiveness of intravenous flunitrazepam administration for prolonged seizures was clinically examined, and in some patients, the time course of the serum flunitrazepam concentration was determined. Flunitrazepam appeared to be clinically effective and safe for prolonged seizures. The time course of serum flunitrazepam concentration was as previously reported. In this study, we suggest that intravenous flunitrazepam administration is effective for prolonged seizures.