Clinical effectiveness of intravenous flunitrazepam administration for prolonged seizures

Abstract

For the treatment of prolonged seizures in children, the use of diazepam is well established. Flunitrazepam, a benzodiazepine derivative like diazepam, has also been reported to relieve prolonged seizures. In this study, the effectiveness of intravenous flunitrazepam administration for prolonged seizures was clinically examined, and in some patients, the time course of the serum flunitrazepam concentration was determined. Flunitrazepam appeared to be clinically effective and safe for prolonged seizures. The time course of serum flunitrazepam concentration was as previously reported. In this study, we suggest that intravenous flunitrazepam administration is effective for prolonged seizures.

Keywords

Prolonged seizures - diazepam - flunitrazepam - benzodiazepines - intravenous administration