Abstract
To evaluate ictal serum levels of heart type fatty acid binding protein (H-FABP) in
children with intractable epilepsy as a marker of cardiac ischemia in comparison to
their levels in the interictal period and that of controls. The study included 23
seizure episodes recorded in 14 patients with intractable seizures. Serum levels of
H-FABP in the ictal and interictal periods were done as well as simultaneous electrocardiogram,
Holter and video electroencephalography recordings with evaluation of changes in the
heart rate (HR), and HR variability parameters. Levels of H-FABP were higher in the
patients' group whether in the ictal or interictal periods compared to the control
group. However, levels were not significantly different in the ictal period compared
to the interictal one. Ictal tachycardia was recorded in 95% and bradycardia in 5%
of the studied seizures episodes. Premature atrial and ventricular contractions were
recorded in the 1st postictal hour of 8.7% and 30.4% of the recorded seizures, respectively. Interictal
values showed significant increase minutes before the onset of the seizures and remained
high 2 hours postictally. All time domain HR variability parameters were lower in
the patients' group. Our results showed significant increase in the serum levels of
H-FABP in our patients' group, which might suggest a degree of myocardial ischemia
even in asymptomatic patients. Though bradycardia, prolonged QTc and arrhythmic changes
were reported in few cases, the importance of the results warrants studying those
changes at least in patients with refractory seizures.
Keywords
Epilepsy - heart rate - heart rate variability - heart type fatty acid binding protein
- Holter
