Cyclosporine-induced PRES in a child recipient of allogeneic bone marrow transplantation

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a recently described clinic-radiological entity. It has been associated with a number of medical conditions, such as eclampsia, arterial hypertension, renal failure, and vasculitis. Drugs causing immunosuppression such as cyclosporine A, tacrolimus, cancer chemotherapy, and steroids have been implicated in the etiology of PRES. Its pathogenesis remains poorly understood. Clinical findings are not sufficiently specific; however, neuroimaging is often characteristic. Few cases of PRES were reported in children who were treated for cancer, most of whom had acute lymphoblastic leukemia. This case-report describes PRES following allogeneic bone marrow transplantation in a child with acute lymphocytic leukemia.

Keywords

PRES - cyclosporine - BMT