J Pediatr Infect Dis 2012; 07(01): 041-044
DOI: 10.3233/JPI-2012-0341
Georg Thieme Verlag KG Stuttgart – New York

Disseminated neonatal Herpes simplex virus infection preceded by four days of prenatal maternal fever

K. Courtney Meena
a  Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA
,
Clare C. Nesmith
a  Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA
,
Kristine G. Palmer
a  Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA
,
Richard F. Jacobs
a  Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA
,
Bryan L. Burke Jr.
a  Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, AR, USA
› Author Affiliations

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Further Information

Publication History

05 December 2011

27 December 2011

Publication Date:
28 July 2015 (online)

Abstract

A quick diagnosis for disseminated neonatal Herpes simplex virus (HSV) infection is not easy, potentially affecting morbidity and mortality. We report a case of disseminated HSV occurring at 4 days of life whose mother had fever for 4 days before delivery, a negative history for all sexually transmitted diseases, and a normal genitourinary examination (including visual examination of external genitalia and cervical/vaginal mucosa without colposcopy). A septic work-up done at birth was negative. A second septic work-up at 4 days of age, after clinical deterioration, led to the correct diagnosis and therapy. This case illustrates some of the difficulties in making a rapid diagnosis of neonatal HSV in all cases, especially at this age, and emphasizes the need for inclusion in this differential diagnosis and appropriate presumptive therapy.