J Pediatr Infect Dis 2012; 07(01): 001-007
DOI: 10.3233/JPI-2012-0339
Georg Thieme Verlag KG Stuttgart – New York

Changing clinical profile of Dengue infection: A newer perspective in the pediatric population

Satarupa Mukherjee
a  Department of Pediatrics, Medical College and Hospital, Kolkata, India
,
Souvik Mitra
a  Department of Pediatrics, Medical College and Hospital, Kolkata, India
,
Moumita Samanta
a  Department of Pediatrics, Medical College and Hospital, Kolkata, India
,
Prithwish Roy
a  Department of Pediatrics, Medical College and Hospital, Kolkata, India
,
Mihir Sarkar
a  Department of Pediatrics, Medical College and Hospital, Kolkata, India
,
Sukanta Chatterjee
a  Department of Pediatrics, Medical College and Hospital, Kolkata, India
› Institutsangaben

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Publikationsverlauf

14. September 2011

03. April 2012

Publikationsdatum:
28.Juli 2015 (online)

Abstract

Background: Traditionally complications of Dengue infection is limited to vascular and haematological system. The present study describes the changing clinico-epidemiological and laboratory profile of children hospitalized with dengue infection. Methods: Prospective observational study of children hospitalized with a diagnosis of dengue illness from October to December, 2010 at a tertiary care centre in Kolkata. Results: Of 50 children admitted with dengue infection, 24 had dengue fever (DF), 18 dengue hemorrhagic fever (DHF) and 8 had dengue shock syndrome (DSS). The mean age of affected children was 6.25 ± 3.34 years, mostly being males from rural areas. The common clinical manifestations were fever, rash, body ache, hemorrhagic manifestations and oedema. While headache and body ache was commoner among DF cases, rash and hemorrhagic manifestations were significantly more among DHF group. Incidence of altered sensorium, neck rigidity, fulminant hepatitis, and splenomegaly were significantly higher among the DHF/DSS group. 12% case fatality rate was found. Conclusion: Clinical manifestations of dengue seem to be changing. Fever, rash and bodyache are not the only clinical presentations. Encephalopathy, encephalitis, 6th cranial nerve palsy, fulminant hepatic failure, acute acalculous cholecystitis, myocarditis, myelitis, splenomegaly are some unusual but novel presentations of dengue in pediatric population that clinician in endemic area should be aware of though they are not mentioned in conventional guidelines Dengue is no longer restricted to urban areas but has propensity to spread to rural areas also.