Abstract
Elizabethkingia meningoseptica is known to cause meningitis in premature neonates and severe infections in immunocompromised
adults. It may cause a therapeutic dilemma as it often shows discrepancies between
various methods of antimicrobial susceptibility testing. Here, we present a case of
multi drug resistant E. meningoseptica meningitis and sepsis in a premature baby, which caused a therapeutic challenge.
The strain was susceptible to piperacillin, piperacillin-tazobactam and trimethoprim/sulfamethoxazole
by disk diffusion method. On the other hand the minimum inhibitory concentration values
for these antibiotics were much higher to be interpreted as resistant by VITEK 2C
(bioMérieux). This case showed significant clinical improvement with combination therapy
of piperacillin-tazobactam and amikacin, and the same drugs were continued. Relying
on the clinical outcome in this case, we observe that VITEK 2C may be less accurate
than disk diffusion method for detection of antimicrobial resistance in this organism.
Keywords
Elizabethkingia meningoseptica
- meningitis - sepsis - premature neonate - disk diffusion - VITEK 2C
