J Pediatr Infect Dis 2009; 04(04): 321-331
DOI: 10.3233/JPI-2009-0197
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Rheumatic manifestations of Epstein-Barr virus in children

Brooke E. Gilliam
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, Missouri USA
,
Melinda R. Reed
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, Missouri USA
,
Reema H. Syed
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, Missouri USA
,
Terry L. Moore
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, Missouri USA
› Author Affiliations

Subject Editor:
Further Information

Publication History

05 December 2008

13 March 2009

Publication Date:
28 July 2015 (online)

Abstract

Epstein-Barr virus (EBV) is known to cause infectious mononucleosis; in addition, it is strongly associated with malignancies. Studies have also demonstrated that EBV infection may trigger the development of systemic lupus erythematosus. EBV infection has been implicated in complicating treatment of juvenile idiopathic arthritis, in addition to triggering cytokine production. Awareness of a past or present EBV infection has been highlighted as an important factor in determining treatment options in several diseases. Repeated associations have been described between EBV infection and various rheumatic diseases and complications of rheumatic disease, including Kawasaki disease, immune thrombocytopenic purpura, and hemophagocytic lymphohistiocytosis. We present a review of recent literature demonstrating the significance of EBV infection in rheumatic diseases, and complications of rheumatic disease, in children.