J Pediatr Infect Dis 2009; 04(04): 333-342
DOI: 10.3233/JPI-2009-0195
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Rheumatic manifestations of parvovirus B19 in children

Melinda R. Reed
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
,
Brooke E. Gilliam
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
,
Reema H. Syed
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
,
Terry L. Moore
a  Division of Adult and Pediatric Rheumatology, Saint Louis University School of Medicine, Saint Louis, MO, USA
› Author Affiliations

Subject Editor:
Further Information

Publication History

07 October 2008

05 February 2009

Publication Date:
28 July 2015 (online)

Abstract

It is well known that parvovirus B19 causes erythema infectiosum, a common febrile exanthema of childhood. Studies have also shown that parvovirus B19 can cause chronic arthropathy in children, and some children may meet classification criteria for juvenile idiopathic arthritis. A child’s anti-B19 antibodies may cross-react with other antigens leading to autoantibody formation and immune complex deposition. This process can cause a similar clinical picture to systemic lupus erythematosus, and in some cases has been implicated in initiation of disease. Parvovirus B19 has also been linked to the presence of antiphospholipid antibodies, juvenile dermatomyositis, vasculitides, immune thrombocytopenic purpura, and hemophagocytic lymphohistiocytosis. This review provides an extensive evaluation of the literature on parvovirus B19 and its role in rheumatic diseases in children.