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J Pediatr Infect Dis 2013; 08(01): 043-047
DOI: 10.3233/JPI-130374
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Candida krusei arthritis in a boy with acute lymphoblastic leukemia

Masaki Yamamoto
a   Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
,
Tsukasa Hori
a   Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
,
Naoki Hatakeyama
a   Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
,
Keita Igarashi
a   Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
,
Hiroyuki Tsutsumi
a   Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan
,
Nobuhiro Suzuki
b   Hokkaido Medical Center for Child Health and Rehabilitation, Sapporo, Japan
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Publication History

17 October 2012

03 January 2013

Publication Date:
28 July 2015 (online)

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Abstract

Fungal arthritis is a relatively rare complication, which occurs in patients with hematological disease and cancer. Recently non-albicans Candida species have emerged as clinically important agents; however, Candida krusei (C. krusei) arthritis is still rare. We report a 6-year-old boy who developed C. krusei arthritis associated with acute lymphoblastic leukemia. He was given oral fluconazole and broad-spectrum antibiotics prophylactically, but nevertheless, he developed fungemia with C. krusei and subsequently developed arthritis in his right hip. He was successfully treated with liposomal amphotericin B and micafungin combined with surgical drainage. This is the youngest case with C. krusei arthritis.

Keywords

Fungal arthritis - acute lymphoblastic leukemia - C. krusei - liposomal amphotericin B - micafungin