J Pediatr Infect Dis 2012; 07(03): 135-138
DOI: 10.3233/JPI-120359
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Use of daptomycin in neonates: A case report and review of the literature

Rohit Aswani
a  Department of Pediatrics, Marshall University Huntington, WV, USA
,
Maria G. Lopez Marti
a  Department of Pediatrics, Marshall University Huntington, WV, USA
› Author Affiliations

Subject Editor:
Further Information

Publication History

13 February 2012

07 March 2012

Publication Date:
28 July 2015 (online)

Abstract

We report a case of persistent bacteremia secondary to methicillin-resistant S. aureus (MRSA) in a preterm neonate successfully treated with daptomycin. Although the MRSA isolate was susceptible to vancomycin, there was no clinical or microbiologic response. Within 3 days of therapy with daptomycin, clinical improvement was noted, along with sterilization of blood cultures. Little data exist on neonatal pharmacokinetics of daptomycin. This report highlights the potential advantage that daptomycin offers in treating severe MRSA infections in neonates.