J Pediatr Infect Dis 2012; 07(03): 127-130
DOI: 10.3233/JPI-120358
Case Report
Georg Thieme Verlag KG Stuttgart – New York

Intravenous Anti-D immunoglobulin for control of life threatening bleed in dengue hemorrhagic fever with severe thrombocytopenia

Nilay Nirupam
a  Department of Pediatrics, Division of Pediatric Intensive Care, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
,
Sandeep Kumar
a  Department of Pediatrics, Division of Pediatric Intensive Care, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
,
Sushant Badatya
a  Department of Pediatrics, Division of Pediatric Intensive Care, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
,
Viswas Chhapola
a  Department of Pediatrics, Division of Pediatric Intensive Care, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
,
Rajni Sharma
a  Department of Pediatrics, Division of Pediatric Intensive Care, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
,
Virendra Kumar
a  Department of Pediatrics, Division of Pediatric Intensive Care, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India
› Author Affiliations

Subject Editor:
Further Information

Publication History

12 April 2012

18 June 2012

Publication Date:
28 July 2015 (online)

Abstract

We report an eight-year-old girl with Dengue Hemorrhagic Fever, shock and a life-threatening upper gastrointestinal and pulmonary bleed with refractory thrombocytopenia. She received 6 units of random donor platelets, 1 unit of single donor platelets, 1 unit of packed red cells and 4 units of fresh frozen plasma to control bleeding but had no response. Finally, 36 hour after onset of bleed intravenous Anti-D 75 μg/kg was given and she had a dramatic increase in platelet counts and cessation of all clinical bleed. This case report highlights that intravenous Anti-D can be a treatment option in Dengue Hemorrhagic Fever with severe refractory thrombocytopenia and massive bleeding.