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CC BY 4.0 · Brazilian Journal of Oncology 2017; 13(45): e-BJO20171345A34
DOI: 10.26790/BJO20171345A34
Relato de Caso

Simultaneous transmission of adenocarcinoma after kidney transplantation. Report of two rare cases

Transmissão simultânea de adenocarcinoma após transplante renal. Relato de 2 casos raros
Pedro Exman
1   Instituto do Cancer do Estado de São Paulo, São Paulo, SP, Brazil
,
Sibele Inacio Meireles
2   Hospital Sírio-Libanês, São Paulo, SP, Brazil
,
Renata Couldry
2   Hospital Sírio-Libanês, São Paulo, SP, Brazil
,
Elias David Neto
3   Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil
,
Jorge Sabbaga
1   Instituto do Cancer do Estado de São Paulo, São Paulo, SP, Brazil
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ABSTRACT

Malignancy related to donor after transplantation is a very rare situation that can be classified in two categories. The first is donor cell derived malignancy and the second, most rare, is tumor transmission which include the development of malignancy in a misdiagnosed donor pre-existent solid organ. This condition has good prognosis mainly because of recipient immune response, and patients are treated with explatantion of the graft associated with immunotherapy withdraw. Accordingly, we report two cases of female patients that have received their kidneys and tumors transplanted from the same male donor which DNA analysis confirm the same donor origin. Both patients were treated with the same therapy but different disease presentation.

RESUMO

Neoplasia associada ao transplante de orgãos é uma situacão extremamente rara que pode ser classificada em 2 duas categorias. A primeira quando o tumor se desenvolve da célula do doador após a realização do transplante, e a segunda, mais rara, é a transmissão para o receptor de tumores metastáticos pré-existentes e não diagnosticados do doador. Apesar de rara, esta situação apresenta um bom prognóstico e os pacientes são tratados com a retirada do enxerto e a suspensão da imunossupressão. Neste artigo, relatamos 2 mulheres que foram diagnosticadas com tumores transmitidos pelo mesmo doador do sexo masculino após serem submetidas a transplantes renais, com confirmação da mesma origem tumoral por análise de DNA.

Keywords:

Adenocarcinoma - Transplantation - Transmission - Neoplasms/immunology

Descritores:

Adenocarcinoma - Transplante - Transmissão - Neoplasias/imunologia


Publikationsverlauf

Eingereicht: 01. Februar 2017

Angenommen: 06. September 2017

Artikel online veröffentlicht:
25. Februar 2025

© 2017. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/)

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Bibliographical Record
Pedro Exman, Sibele Inacio Meireles, Renata Couldry, Elias David Neto, Jorge Sabbaga. Simultaneous transmission of adenocarcinoma after kidney transplantation. Report of two rare cases. Brazilian Journal of Oncology 2017; 13: e-BJO20171345A34.
DOI: 10.26790/BJO20171345A34
 

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