Download PDF
Arquivos Internacionais de Otorrinolaringologia 2011; 15(03): 359-364
DOI: 10.1590/S1809-48722011000300015
Review Article
Thieme Publicações Ltda Rio de Janeiro, Brazil

Laryngeal sarcoidosis: Literature review

Sarcoidose laríngea: Revisão de literatura
Bruno Teixeira de Moraes
1   Otorhinolaryngologist. Taking Master Degree at the Federal University of São Paulo's Department of Otorhinolaryngology and Head and Neck Surgery (UNIFESP-EPM).
,
Luciano Rodrigues Neves
2   Otorhinolaryngologist. Taking Doctorate Degree at the Federal University of São Paulo's Department of Otorhinolaryngology and Head and Neck Surgery (UNIFESP-EPM).
,
Osíris de Oliveira Camponês do Brasil
3   Otorhinolaryngologist. Professor Doctor at the Federal University of São Paulo's Department of Otorhinolaryngology and Head and Neck Surgery (UNIFESP-EPM).
,
José Eduardo de Sá Pedroso
4   Otorhinolaryngologist. Assistant Professor at the Federal University of São Paulo's Department of Otorhinolaryngology and Head and Neck Surgery (UNIFESP-EPM).
,
Jose Elson Santiago de Melo Junior
5   Doctor. Taking Specialization Degree in Otorhinolaryngology at the Federal University of São Paulo (UNIFESP-EPM).
› Author Affiliations
Further Information

Publication History

23 January 2010

24 April 2010

Publication Date:
12 February 2014 (online)

   Permissions and Reprints

Summary

Introduction: Laryngeal sarcoidosis is a granulomatous disease representing a challenge as regards diagnosis and treatment.

Method: In this review, all aspects of the disease are involved, including etiology, clinical manifestations in adults and children, diagnosis, and treatment, by searching through Medline, Lilacs and Scielo databases, as well as English and Portuguese articles published from 1973 to 2008.

Final Comments: Despite the breakthroughs in its diagnosis and treatment, sarcoidosis is a disease that remains without a clear etiology and physiopathology, becoming an exclusion diagnosis due to both the lack of precise exams and its likely multifactor background. Laryngeal impairment, however infrequent, is a suspicion mainly when there is a precedent history of systemic sarcoidosis, and the research for differentiated diagnosis must be wide-ranging so as to prevent severe diseases like malign neoplasia from being unnoticed.

Resumo

Introdução: A sarcoidose laríngea é uma doença granulomatosa que representa um desafio em relação ao diagnóstico e o tratamento.

Método: Nesta revisão são abordados todos os aspectos da doença, incluindo etiologia, manifestações clínicas em adultos e crianças, diagnóstico e tratamento, a partir da base de dados Medline, Lilacs e Scielo, incluindo-se artigos de língua inglesa e portuguesa publicados no período de 1973 a 2008.

Comentários Finais: Apesar dos avanços ocorridos na investigação e tratamento da sarcoidose, é uma doença que ainda se mantém sem etiologia e fisiopatologia definidas, constituindo um diagnóstico de exclusão pela ausência de exames específicos e por sua provável origem multifatorial. O acometimento laríngeo, apesar de raro, é suspeitado principalmente diante de história prévia de sarcoidose sistêmica, e a pesquisa dos diagnósticos diferenciais deve ser extensa para não passarem desapercebidas doenças graves como neoplasias malignas.

Keywords

laryngeal disease - sarcoidosis - larynx - positron emission tomography

Palavras-chave

doenças da laringe - sarcoidose - laringe - tomografia por emissão de pósitrons
 

  • References

  • 1 Schwartzbauer HR, Tami TA. Ear, nose and throat manifestations of sarcoidosis. Otolaryngol Clin N Am 2003; 36: 673-84
    CrossrefGoogle Scholar
  • 2 James DG, Hosoda Y. Epidemiology in sarcoidosis and other granulomatous disorders. New York: Marcel Dekker; 1994. . (Lung biology in health and disease).
    Google Scholar
  • 3 Bethlem NM. Epidemiology of sarcoidosis in Brazil. Sarcoidosis 1985; 2: 162
    Google Scholar
  • 4 Neel III HB, McDonald TJ. Laryngeal sarcoidosis: report of 13 patients. Ann Otol Rhinol Laryngol 1982; 91 (4 Pt 1): 359-62
    Google Scholar
  • 5 Fortune S, Courey MS. Isolated laryngeal sarcoidosis. Otolaryngol Head Neck Surgery 1998; 118 (6) 868-70
    CrossrefGoogle Scholar
  • 6 Weinberger SE. Sarcoidosis. In: Goldman: Cecil medicine. Philadelphia: Elsevier Saunders; 2007. . chapter 95.
    Google Scholar
  • 7 Shigehara K, Shijubo N, Ohmichi M , et al. Enhanced mRNA expression of Th1 cytokines and IL-12 in active pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2000; 17 (2) 151-7
    Google Scholar
  • 8 Newman LS, Rose CS, Bresnitz EA, Rossman MD, Barnard J, Frederick M , et al. A case control etiologic study of sarcoidosis: environmental and occupational risk factors. Am J Respir Crit Care Med 2004; 170: 1324-1330
    CrossrefPubMedGoogle Scholar
  • 9 Brennan NJ, Crean P, Long JP , et al. High prevalence of familial sarcoidosis in an Irish population. Thorax 1984; 39 (1) 14-8
    CrossrefGoogle Scholar
  • 10 Abe S, Yamaguchi E, Makimura S , et al. Association of HLA-DR with sarcoidosis. Correlation with clinical course. Chest 1987; 92 (3) 488-90
    Google Scholar
  • 11 Rossman MD, Thompson B, Frederick M , et al. HLA-DRB1 1101: a significant risk factor for sarcoidosis in blacks and whites. Am J Hum Genet 2003; 73: 720-35
    CrossrefPubMedGoogle Scholar
  • 12 Iannuzzi MC, Maliarik MJ, Poisson LM, Rybicki BA. Sarcoidosis susceptibility and resistance HLA-DQB1 alleles in African Americans. Am J Respir Crit Care Med 2003; 167: 1225-31
    CrossrefGoogle Scholar
  • 13 Heyll A, Meckenstock G, Aul C , et al. Possible transmission of sarcoidosis via allogeneic bone marrow transplantation. Bone Marrow Transplant 1994; 14 (1) 161-4
    Google Scholar
  • 14 Moller DR, Chen ES. What causes sarcoidosis?. Current Opinion in Pulmonary Medicine 2002; 8: 429-434
    CrossrefGoogle Scholar
  • 15 Siltzbach LE, James DG, Neville E , et al. Course and prognosis of sarcoidosis around the world. Am J Med 1974; 57 (6) 847-52
    CrossrefGoogle Scholar
  • 16 Winterbauer RH, Belic N, Moores KD. Clinical interpretation of bilateral hilar adenopathy. Ann Intern Med 1973; 78 (1) 65-71
    CrossrefGoogle Scholar
  • 17 Vaz FM, Samuel D. Postcricoid sarcoid mimicking a malignancy: A lesson to remember. Otolaryngol Head Neck Surg 2000; 123: 150
    CrossrefGoogle Scholar
  • 18 Benjamin B, Dalton C, Croxson G. Laryngoscopic Diagnosis Of Laryngeal Sarcoid. Ann Otol Rhinol Laryngol 1995; 104: 529-31
    Google Scholar
  • 19 Dean CM, Sataloff RT, Hawkshaw MJ, Pribikin E. Laryngeal sarcoidosis. J Voice 2002; 16 (2) 283-8
    CrossrefPubMedGoogle Scholar
  • 20 Hernández PE, Casas AA, Massana EF , et al. Sarcoidosis Laríngea Aislada. Acta Otorrinolaringol Esp 2003; 54: 117-20
    CrossrefGoogle Scholar
  • 21 Caporrino Neto J, Cervantes O, Jotz GP, Abrahão M. Doenças granulomatosas da Laringe. Acta Awho 1998; 17 (1) 6-10
    Google Scholar
  • 22 Bower JS, Belen JE, Weg JG, Dantzer DR. Manifestations and treatment of laryngeal sarcoidosis. Am Rev Respir Dis 1980; 122: 325-32
    PubMedGoogle Scholar
  • 23 Hoffmann AL, Milman N, Byg KE. Childhood sarcoidosis in Denmark 1979-1994: incidence, clinical features and laboratory results at presentation in 48 children. Acta Paediatr 2004; 93: 30-6
    CrossrefGoogle Scholar
  • 24 Kendig EL. The clinical picture of sarcoidosis in children. Pediatrics 1974; 54: 289-92
    Google Scholar
  • 25 Kendig EL, Brummer DL. The prognosis of sarcoidosis in children. Chest 1976; 70: 351-353
    CrossrefGoogle Scholar
  • 26 Kenny TJ, Werkhaven J, Netterville JL. Sarcoidosis of the Pediatric Larynx. Arch Otolaryngol Head Neck Surg 2000; 126: 536-39
    CrossrefGoogle Scholar
  • 27 Rybak L, Falconeer R. Pediatric Laryngeal Sarcoidosis. Ann Otol Rhinol Laryngol 1987; 96: 670-73
    Google Scholar
  • 28 Palacios E, Smith A, Gupta N. Laryngeal sarcoidosis. Ear, Nose and Throat Journal 2008; 252-53
    Google Scholar
  • 29 Kaira K, Ishizuka T, Yanagitani N, Sunaga N, Hisada T, Mori M. Laryngeal Sarcoidosis Detected by FDG Positron Emission Tomography. Clin Nucl Med 2008; 33: 878-79
    CrossrefGoogle Scholar
  • 30 Avram AM, Mackie GC, Schneider BJ , et al. Differentiation between carcinoid and sarcoid with F-18 FDG PET and In-111 pentetreotide. Clin Nucl Med 2006; 31: 197-200
    CrossrefGoogle Scholar
  • 31 Braun JJ, Imperiale A, Schultz P, Molard A, Charpiot A, Gentine A. Pharyngolaryngeal sarcoidosis: Report of 12 cases. Otolaryngology-Head and Neck Surgery 2008; 139: 463-65
    Google Scholar
  • 32 Gal AA, Koss MN. The pathology of sarcoidosis. Current Opinion in Pulmonary Medicine 2002; 8: 445-451
    CrossrefGoogle Scholar
  • 33 Iannuzzi MC, Rybicki BA, Teirstein AS. Sarcoidosis. N Engl J Med 2007; 357: 2153-65
    CrossrefGoogle Scholar
  • 34 Martinez JAB. Doenças intersticiais pulmonares. Medicina 1998; 31: 247-256
    Google Scholar
  • 35 Newman LS, Rose CS, Maier LA. Sarcoidosis. N Engl J Med 1997; 336 (17) 1224-1234
    CrossrefGoogle Scholar
  • 36 Baughman RP, Lower EE. A clinical approach to the use of methotrexate for sarcoidosis. Thorax 1999; 54 (8) 742-6
    CrossrefPubMedGoogle Scholar
  • 37 Lewis SJ, Ainslie GM, Bateman ED. Efficacy of azathioprine as second-line treatment in pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 1999; 16 (1) 87-92
    Google Scholar
  • 38 Carasso B. Sarcoidosis of the larynx causing airway obstruction. Chest 1974; 65 (6) 693-5
    CrossrefGoogle Scholar