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DOI: 10.1590/0004-282X20200079
Migrainous periorbital ecchymosis
Equimose periorbitária na enxaqueca
A 27-year-old woman, with migraine with aura since age 9, developed two episodes of alternating periocular ecchymosis, with one-month interval, which happened a few hours after the headache onset ([Figure 1]). The pain lasted more than usual (48 to 72 hours), and the ecchymosis persisted from three to four days. After over two years of follow-up, there was no recurrence of such episodes.


The spontaneous periorbital hematoma/ecchymosis in migraine is a rare entity assumed to reflect complex neurovascular changes[1],[2], specifically vasodilation of intracranial and extracerebral blood vessels through the release of vasoactive substances[3].
Authors’ contributions:
Duarte S: manuscript preparation; writing the first draft; critical revision of the manuscript. Andrade A: Conceived the idea of the manuscript; supervision; critical revision of the manuscript.
Publication History
Received: 21 April 2020
Accepted: 04 May 2020
Article published online:
13 June 2023
© 2020. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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References
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- 2 Obermann M, Yoon MS, Dommes P, Kuznetsova J, Maschke M, Weimar C, et al. Prevalence of trigeminal autonomic symptoms in migraine: a population-based study. Cephalalgia. 2007 Jun;27(6):504-9. https://doi.org/10.1111/j.1468-2982.2007.01316.x
- 3 Kalendovsky Z, Austin JH. Changes in blood clotting systems during migraine attacks. Headache. 1977 Jan;16(6):293-312. https://doi.org/10.1111/j.1526-4610.1976.hed1606293.x