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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2020; 78(10): 624-628
DOI: 10.1590/0004-282X20200045
Original Article

Validation of 19-items wearing-off (WOQ-19) questionnaire to Portuguese

Validação do questionário de 19 itens de wearing-off (WOQ-19) para a língua portuguesa
Carlos Eduardo MANTESE 
1   Universidade Federal do Rio Grande do Sul, Programa de Pós-graduação em Ciências Médicas, Porto Alegre RS, Brazil.
2   Hospital Mãe de Deus, Porto Alegre RS, Brazil.
,
Marcio MEDEIROS 
1   Universidade Federal do Rio Grande do Sul, Programa de Pós-graduação em Ciências Médicas, Porto Alegre RS, Brazil.
,
Artur SCHUMACHER-SCHUH 
1   Universidade Federal do Rio Grande do Sul, Programa de Pós-graduação em Ciências Médicas, Porto Alegre RS, Brazil.
3   Hospital de Clínicas de Porto Alegre, Porto Alegre RS, Brazil.
,
Carlos Roberto de Melo RIEDER 
1   Universidade Federal do Rio Grande do Sul, Programa de Pós-graduação em Ciências Médicas, Porto Alegre RS, Brazil.
4   Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre RS, Brazil.
› InstitutsangabenGefördert durch: Conselho Nacional de Desenvolvimento Científico e Tecnológico 311970/2014-1
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ABSTRACT

Background: The treatment of Parkinson disease with dopaminergic therapy improves functionality and quality of life. However, as the disease progresses, the wearing-off phenomenon develops. To improve the recognition of this phenomenon, the 19-item wearing-off questionnaire (WOQ-19) was developed. Objective: To translate and validate the WOQ-19 into Portuguese. Methods: The questionnaire was translated into Portuguese and, subsequently, back-translated into English and analyzed. The final version was tested in Parkinson disease patients for reliability through the test-retest paradigm and internal consistency. Also, sensitivity and specificity were obtained in different cut-off positive items. Results: The WOQ-19 showed good test stability, with an intraclass correlation coefficient of 0.877 (95%CI 0.690-0.951; p<0.001), and good internal consistency, with Cronbach alpha of 0.815. Two items of positive cut-off showed the best accuracy: 0.873 (95%CI 0.791-0.954). Sensitivity was 0.975 (95%CI 0.892-1) and specificity was 0.714 (95%CI 0.565-0.863). Conclusion: The Portuguese version of the WOQ-19 showed excellent diagnostic properties and can be used to diagnose wearing-off phenomena.

RESUMO

Introdução: O tratamento da doença de Parkinson com terapia dopaminérgica melhora a funcionalidade e a qualidade de vida. Entretanto, com a progressão da doença, os fenômenos de flutuação motora e não motora se desenvolvem. Para melhorar o reconhecimento dessa situação, foi desenvolvido o questionário de 19 itens de wearing-off (WOQ-19) Objetivo: Traduzir e validar o questionário WOQ-19 para a língua portuguesa. Métodos: O questionário foi traduzido do inglês para o português. Em seguida, foi retrotraduzido para o inglês e analisado. A versão final foi testada em pacientes parkinsonianos com paradigma teste-reteste e consistência interna. A sensibilidade e especificidade foram medidas em relação a vários pontos de cortes de itens positivos. Resultados: O questionário apresenta boa estabilidade de teste, com coeficiente de correlação intraclasse de 0,877 (IC95% 0,690-0,951; p<0,001), e boa consistência interna, com alfa de Cronbach de 0,815. O ponto de corte com dois itens positivos teve a melhor acurácia: 0,873 (IC95% 0,791-0,954). A sensibilidade foi de 0,975 (IC95% 0,892-1) e a especificidade foi 0,714 (0,565-0,863). Conclusão: A versão em português do WOQ-19 mostrou excelentes propriedades diagnósticas e pode ser utilizada para diagnosticar as condições de flutuações motoras e não motoras na doença de Parkinson.

Keywords:

Parkinson Disease - Antiparkinson Agents

Palavras-chave:

Doença de Parkinson - Antiparkinsonianos

Authors’ contributions:

Conception: Mantese CE and Rieder B. Organization: Mantese CE and Schumacher-Schuh A. Execution: Mantese CE, Medeiros M, Schumacher-Schuh A and Rieder CRM. Statistical Analysis - design: Mantese CE; execution: Mantese CE; review and critique: Mantese CE, Medeiros M, Schumacher-Schuh A and Rieder CRM. Manuscript - writing of the first draft: Mantese CE; review and critique: Mantese CE, Medeiros M, Schumacher-Schuh A and Rieder CRM.


Support:

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).




Publikationsverlauf

Eingereicht: 11. März 2020

Angenommen: 06. April 2020

Artikel online veröffentlicht:
13. Juni 2023

© 2020. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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