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CC BY-NC-ND 4.0 · Arq Neuropsiquiatr 2020; 78(02): 70-75
DOI: 10.1590/0004-282X20190139
Article

Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate

Via auditiva em tronco encefálico de crianças com leucemia linfoide aguda em quimioterapia com metotrexato
Renata Aparecida LEITE 
1   Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
,
Jéssica Sales VOSGRAU 
1   Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
,
Leticia CORTEZ  NETO
1   Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
,
Nayara Pereira SANTOS 
1   Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
,
Sandro Luiz de Andrade MATAS 
2   Universidade Federal de São Paulo, Setor de Medicina Laboratorial, Departamento de Medicina, São Paulo SP, Brazil.
,
Vicente ODONE FILHO
3   Universidade de São Paulo, Faculdade de Medicina, Departamento de Pediatria, São Paulo SP, Brazil.
,
Carla Gentile MATAS 
1   Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
› Author Affiliations Support: Conselho Nacional de Desenvolvimento Científico e Tecnológico como Bolsa de Pós-Doutorado Processo No 166207/2015-2.
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ErratumArq Neuropsiquiatr 2020; 78(04): 244-244
DOI: 10.1590/0004-282x20190139erratum

Abstract

Objective: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). Methods: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. Results: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. Conclusion: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.

Resumo

Objetivo: Investigar a via auditiva em tronco encefálico de crianças com leucemia linfoide aguda submetidas à quimioterapia (por infusão intravenosa ou por via intratecal). Métodos: Foram avaliadas 14 crianças com idade entre 2 e 12 anos, com diagnóstico de leucemia linfoide aguda. Foram utilizados os seguintes procedimentos: meatoscopia, medidas de imitância acústica, audiometria tonal, audiometria vocal, emissões otoacústicas transientes e potencial evocado auditivo de tronco encefálico. Resultados: Das 14 crianças com limiares auditivos normais, 35,71% demonstraram alteração no Potencial Evocado Auditivo de Tronco Encefálico, com predomínio de comprometimento de via auditiva em tronco encefálico baixo. Verificou-se que 80% das crianças com alteração haviam feito uso do metotrexato via intratecal a menos de 30 dias e que 40% tinham as maiores doses acumulativas de metotrexato por via endovenosa. Conclusão: Crianças com leucemia linfoide aguda submetidas à quimioterapia apresentam comprometimento na via auditiva em tronco encefálico, com predomínio em tronco encefálico baixo.

Keywords:

hearing - electrophysiology - precursor cell lymphoblastic leukemia-lymphoma - drug therapy - methotrexate - child

Palavras-chave:

audição - eletrofisiologia - leucemia-linfoma linfoblástico de células precursoras - tratamento farmacológico - metotrexato, criança

Support:

Support: Conselho Nacional de Desenvolvimento Científico e Tecnológico como Bolsa de Pós-Doutorado Processo No 166207/2015-2.




Publication History

Received: 23 August 2019

Accepted: 02 September 2019

Article published online:
13 June 2023

© 2020. Academia Brasileira de Neurologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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